Bulletin of Experimental Biology and Medicine

, Volume 147, Issue 1, pp 26–30

Effects of Prolylendopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Experimental Depressive Syndrome Development in Rats

  • N. N. Khlebnikova
  • N. A. Krupina
  • N. G. Bogdanova
  • N. N. Zolotov
  • G. N. Kryzhanovskii
General Pathology and Pathological Physiology

Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine showed that chronic injection of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine 30 min before pro-neurotoxin injection prevents the development of a number of depressive syndrome symptoms such as behavioral despair and biorhythmic disorders in forced swimming test, precludes the increase in anxiety-phobic level, prevents reduction of relative thymus mass. These results indicate that benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine possesses antidepressant, anxiolytic, and/antistress properties.

Key Words

experimental depressive syndrome 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine rats 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • N. N. Khlebnikova
    • 1
  • N. A. Krupina
    • 1
  • N. G. Bogdanova
    • 1
  • N. N. Zolotov
    • 1
  • G. N. Kryzhanovskii
    • 1
  1. 1.Laboratory of General Pathology and Pathophysiology of Nervous System, Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscowRussia

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