Bulletin of Experimental Biology and Medicine

, Volume 146, Issue 6, pp 750–752 | Cite as

Comparative Experimental Pharmacokinetics of Benzimidazole Derivatives

  • S. A. SergeevaEmail author
  • I. L. Gulyaeva
Pharmacology and Toxicology

Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols. Specific features of drug distribution were detected; for example, splenic tissue selectively accumulated thietazole during course treatment.

Key Words

bemithyl etomerzole thietazole pharmacokinetics distribution 


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  1. 1.
    V. A. Myshkin, A. I. Savlukov, I. L. Gulyaeva, et al., Obshchaya Reanimatol., 3, Nos. 5–6, 69–74 (2007).Google Scholar
  2. 2.
    S. A. Sergeeva and I. L. Gulyaeva, Byull. Eksp. Biol. Med., 141, No. 5, 534–536 (2006).CrossRefGoogle Scholar
  3. 3.
    S. A. Sergeeva and I. L. Gulyaeva, Ibid., 145, No. 1, 47–49 (2008).Google Scholar
  4. 4.
    V. N. Solovyov, A. A. Firsov, and V. A. Filov, Pharmacokinetics [in Russian], Moscow (1980).Google Scholar
  5. 5.
    A. A. Spasov, L. A. Smirnova, I. Ya. Iezhitsa, et al., Vopr. Med. Khim., 48, No. 3, 233–258 (2002).PubMedGoogle Scholar
  6. 6.
    F. C. Cheng, Y. E. Ho, L. C. Hung, et al., J. Chromatogr. A., 949 1–2, 35–42 (2002).PubMedCrossRefGoogle Scholar
  7. 7.
    X. N. Zhang, Q. Zhang, H. Wen, et al., Yao Xue Xue Bao, 38, No. 6, 462–466 (2003).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  1. 1.Research Center of Bioactive Substances SafetyStaraya Kupavna, Moscow RegionRussia

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