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Bulletin of Experimental Biology and Medicine

, Volume 145, Issue 4, pp 464–466 | Cite as

Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice

  • I. I. Tepkeeva
  • E. V. Moiseeva
  • A. V. Chaadaeva
  • E. V. Zhavoronkova
  • Yu. V. Kessler
  • S. G. Semushina
  • V. P. Demushkin
Oncology

Abstract

We studied antitumor effects of peptide extracts from plants on slowly growing mammary adenocarcinoma in CBRB-Rb(8.17)1Iem mice used as a model of breast cancer in humans. The antitumor effect of a single injection of the test peptides was evaluated by the delay of the appearance and growth of palpable breast cancer in mice over 4 weeks. Peptides from Hypericum perforatum and a mixture of Chelidonium majus L., Inula helenium L., Equisetum arvense L., and Inonotus obliquus exhibited maximum activity. Peptide extracts from Frangula alnuc Mill. and Laurus nobilis L. were less active. No antitumor effect of Camelia sinesis Kuntze was detected.

Key Words

plant peptides experimental model of human breast cancer CBRB-Rb(8.17)1Iem mice antitumor activity 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • I. I. Tepkeeva
    • 1
  • E. V. Moiseeva
    • 1
  • A. V. Chaadaeva
    • 1
  • E. V. Zhavoronkova
    • 1
  • Yu. V. Kessler
    • 1
  • S. G. Semushina
    • 1
  • V. P. Demushkin
    • 1
  1. 1.M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic BiochemistryRussian Academy of SciencesMoscowRussia

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