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Bulletin of Experimental Biology and Medicine

, Volume 145, Issue 3, pp 358–361 | Cite as

Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles

  • E. I. Shishatskaya
  • A. V. Goreva
  • O. N. Voinova
  • E. V. Inzhevatkin
  • R. G. Khlebopros
  • T. G. Volova
Oncology

Abstract

An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.

Key Words

microencapsulation rubomycin absorbable polymers polyhydroxybutyrate Ehrlich’s ascitic carcinoma 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • E. I. Shishatskaya
    • 1
  • A. V. Goreva
    • 2
  • O. N. Voinova
    • 1
  • E. V. Inzhevatkin
    • 3
  • R. G. Khlebopros
    • 1
  • T. G. Volova
    • 2
  1. 1.Institute of BiophysicsSiberian Division of Russian Academy of SciencesKrasnoyarskRussia
  2. 2.Siberian Federal UniversityKrasnoyarskRussia
  3. 3.International Center for Studies of Critical ConditionsPresidium of Krasnoyarsk Research Center of Siberian Division of Russian Academy of SciencesKrasnoyarskRussia

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