Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 144, Issue 5, pp 699–701 | Cite as

Comparative study of pharmacological activity of Afala on the model of hormone-induced prostatitis in rats

  • K. V. Savelieva
  • T. G. Borovskaya
  • I. A. Kheyfets
  • J. L. Dugina
  • S. A. Sergeeva
  • O. I. Epstein
Article

Abstract

Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa repens extract).

Key Words

hyperprolactinemia benign prostatic hyperplasia prostate-specific antigen ultralow doses 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. G. Avtandilov, Medical Morphometry [in Russian], Moscow (1990).Google Scholar
  2. 2.
    L. M. Gorilovskii, Benign Prostatic Hyperplasia [in Russian], Ed. N. A. Lopatkin, Moscow (1999), pp. 12–20.Google Scholar
  3. 3.
    R. C. Bruskewitz, Rev. Urol., 5, No. 2, 72–80 (2003).PubMedGoogle Scholar
  4. 4.
    V. F. Coppenolle, C. Slomianny, F. Carpentier, et al., Am. J. Physiol. Endocrinol. Metab., 280, 120–129 (2001).Google Scholar
  5. 5.
    F. C. Lowe, C. G. Roehrborn, C. Robertson, and P. Boyle, J. Urol., 159, No. 2, 257 (1998).Google Scholar
  6. 6.
    M. Paubert-Braquet, J. P. Raynaud, P. Braquet, et al., Pharmacol. Res., 31, Suppl., 31–35 (1995).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • K. V. Savelieva
    • 1
  • T. G. Borovskaya
    • 1
  • I. A. Kheyfets
    • 1
  • J. L. Dugina
    • 1
  • S. A. Sergeeva
    • 1
  • O. I. Epstein
    • 1
  1. 1.Materia Medical HoldingMoscow

Personalised recommendations