Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga
Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.
Key Wordsmice Lewis lung adenocarcinoma fucoidan cyclophosphamide cathepsins B, L, and D
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- 1.L. V. Galebskaya, E. V. Ryumina, T. A. Bogomaz, and M. E. Preobrazhenskaya, Biomed. Khimiya, 49, No. 6, 24–27 (2004).Google Scholar
- 2.T. A. Korolenko, S. Ya. Zhanayeva, O. N. Poteryayeva, et al., Byull. Sibirsk. Otdelen. Rossiisk. Akad. Med. Nauk, No. 2, 130–134 (2004).Google Scholar
- 3.T. A. Kuznetsova, N. N. Besednova, A. N. Mamayev, et al., Byull. Eksp. Biol. Med., 136, No. 11, 532–534 (2003).Google Scholar
- 4.T. A. Kuznetsova, T. S. Zaporozhets, N. N. Besednova, et al., Antibiot. Khemoter., 48, No. 4, 11–13 (2003).Google Scholar