Bulletin of Experimental Biology and Medicine

, Volume 143, Issue 6, pp 730–732 | Cite as

Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga

  • T. V. Alekseyenko
  • S. Ya. Zhanayeva
  • A. A. Venediktova
  • T. N. Zvyagintseva
  • T. A. Kuznetsova
  • N. N. Besednova
  • T. A. Korolenko
Article

Abstract

Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.

Key Words

mice Lewis lung adenocarcinoma fucoidan cyclophosphamide cathepsins B, L, and D 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • T. V. Alekseyenko
    • 1
  • S. Ya. Zhanayeva
    • 1
  • A. A. Venediktova
    • 1
  • T. N. Zvyagintseva
    • 2
  • T. A. Kuznetsova
    • 3
  • N. N. Besednova
    • 3
  • T. A. Korolenko
    • 1
  1. 1.Institute of PhysiologySiberian Division of Russian Academy of Medical SciencesNovosibirsk
  2. 2.Pacific Institute of Organic BiochemistryFar-Eastern Division of Russian Academy of SciencesVladivostok
  3. 3.Institute of Epidemiology and MicrobiologySiberian Division of Russian Academy of Medical SciencesVladivostok

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