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Bulletin of Experimental Biology and Medicine

, Volume 143, Issue 3, pp 341–343 | Cite as

Effect of citrocard on functional activity of cardiomyocyte mitochondria during chronic alcohol intoxication

  • V. N. Perfilova
  • O. V. Ostrovskii
  • V. E. Verovskii
  • T. A. Popova
  • S. A. Lebedeva
  • H. Dib
Article

Abstract

Chronic administration of 50% ethanol in a dose of 8 g/kg produces a toxic effect on functional activity of cardiomyocyte mitochondria, which manifested in decreased rates of respiration and oxidative phosphorylation. Structural GABA analogue Citrocard (phenibut citrate) and reference preparation piracetam in doses of 50 and 200 mg/kg, respectively, prevented the damaging effect of alcohol, which was seen from increased indexes of oxidative phosphorylation in treated animals compared to the control group.

Key Words

alcohol intoxication mitochondria oxidative phosphorylation 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. N. Perfilova
    • 1
  • O. V. Ostrovskii
    • 1
  • V. E. Verovskii
    • 1
  • T. A. Popova
    • 1
  • S. A. Lebedeva
    • 1
  • H. Dib
    • 1
  1. 1.Department of Pharmacology and Biopharmacy, Faculty of Postgraduate Medical Training, Institute of PharmacologyVolgograd State Medical UniversityRussia

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