Study of hypoxia-induced expression of HIF-1α in retina pigment epithelium
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- Yanjun, Z., Guangyu, L., Bin, F. et al. Bull Exp Biol Med (2007) 143: 323. doi:10.1007/s10517-007-0101-3
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It was shown that the expression of HIF-1α in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1α reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1α decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1α in RPE. It can be an important step in choriodal neovascularization.