Bulletin of Experimental Biology and Medicine

, Volume 143, Issue 3, pp 323–327

Study of hypoxia-induced expression of HIF-1α in retina pigment epithelium

  • Zeng Yanjun
  • Li Guangyu
  • Fan Bin
  • Wang Qing
  • Jie Ying
  • Liu Aizhen
Article

DOI: 10.1007/s10517-007-0101-3

Cite this article as:
Yanjun, Z., Guangyu, L., Bin, F. et al. Bull Exp Biol Med (2007) 143: 323. doi:10.1007/s10517-007-0101-3

Abstract

It was shown that the expression of HIF-1α in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1α reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1α decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1α in RPE. It can be an important step in choriodal neovascularization.

Key Words

choriodal neovascularization HIF-1α hypoxia retinal pigment epithelium 

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Zeng Yanjun
    • 1
  • Li Guangyu
    • 2
  • Fan Bin
    • 2
  • Wang Qing
    • 3
  • Jie Ying
    • 4
  • Liu Aizhen
    • 4
  1. 1.Biomechanics and Medical Information InstituteBeijing University of TechnologyBeijing
  2. 2.Department of Ophthalmologythe Second Hospital of Jilin UniversityChangchun
  3. 3.Rehabilitation Engineering CentreThe Hong Kong Polytechnic UniversityHong Kong
  4. 4.Department of OptometryBeijing Tongren Eye CenterBeijingChina

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