Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 4, pp 398–402 | Cite as

Peculiarities of autonomic regulation assessed by variability of hemodynamic parameters in rats with different stress resistance

  • T. N. Kirillina
  • M. A. Usacheva
  • L. M. Belkina
Article
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Abstract

Analysis of contribution of sympathetic and parasympathetic systems into heart rate variability carried out using atenolol and atropine showed that August rats are characterized by enhanced tone of the sympathetic system and reduced tone of the parasympathetic system compared to Wistar rats. Reduced tone of the parasympathetic system is also confirmed by lower sensitivity of the baroreflex. Blockade of NO synthesis with Nω-nitro-L-arginine more markedly increased blood pressure variability in August rats compared to Wistar rats. The data attest to a certain rigidity of the autonomic cardiovascular regulation in August rats.

Key Words

heart rhythm spectrum analysis Nω-nitro-L-arginine baroreflex Wistar rats August rast 
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References

  1. 1.
    R. M. Baevskii, Fiziol. Chel., 28, No. 2, 70–82 (2002).Google Scholar
  2. 2.
    L. M. Belkina, T. N. Kirillina, M. G. Pshennikova, and Yu. V. Arkhipenko, Byull. Eksp. Biol. Med., 133, No. 6, 625–628 (2002).CrossRefGoogle Scholar
  3. 3.
    L. M. Belkina, O. S. Tarasova, T. N. Kirillina, et al., Ibid., 136, No. 9, 269–273 (2003).Google Scholar
  4. 4.
    D. Mikoyan, L. N. Kubrina, E. B. Manukhina, et al., Ibid., 121, No. 6, 634–637 (1996).CrossRefGoogle Scholar
  5. 5.
    S. S. Pertsov, E. V. Koplik, V. Krauzer, et al., Ibid., 123, No. 6, 645–648 (1997).CrossRefGoogle Scholar
  6. 6.
    M. G. Pshennikova, N. A. Bondarenko, M. V. Shimkovich, et al., Ibid., 128, No. 12, 638–641 (1999).Google Scholar
  7. 7.
    G. V. Ryabykina and A. V. Sobolev, Heart Rhythm Variability [in Russian], Íoscow (2001).Google Scholar
  8. 8.
    K. V. Sudakov, E. A. Yumatov, and L. S. Ul’yaninskii, Fiziol. Zh. SSSR, No. 11, 1535–1545 (1988).Google Scholar
  9. 9.
    O. Gouedard, J. Blanc, E. Gaudet, et al., Br. J. Pharmacol., 119, No. 6, 1085–1092 (1996).PubMedGoogle Scholar
  10. 10.
    B. J. Janssen, J. Oosting, D. W. Slaaf, et al., Am. J. Physiol., 269, H62–H71 (1995).PubMedGoogle Scholar
  11. 11.
    G. Mancia, C. Giannattasio, D. Turrini, et al., Hyper-tension, 13, S7–S14 (1995).CrossRefGoogle Scholar
  12. 12.
    C. A. Murphy, R. P. Sloan, and M. M. Myers, J. Auton. Nerv. Syst., 36, No. 3, 237–250 (1991).PubMedCrossRefGoogle Scholar
  13. 13.
    D. Ramaekers, F. Beckers, H. Demeulemeester, and A. E. Aubert, Ann. Noninvas. Electrocard., 4, No. 7, 307–318 (2002).CrossRefGoogle Scholar
  14. 14.
    E. Vanoli and P. J. Schwarz, Basic. Res. Cardiol., 85,Suppl. 1, 305–321 (1990).PubMedGoogle Scholar
  15. 15.
    P. Schwarz, R. Diem, N. J. Dun, and U. Fostermann, Circ. Res., 77, 841–848 (1995).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • T. N. Kirillina
    • 1
  • M. A. Usacheva
    • 1
  • L. M. Belkina
    • 1
  1. 1.State Research Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow

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