Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 3, pp 356–359 | Cite as

Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging

  • O. V. Korkushko
  • V. Kh. Khavinson
  • V. B. Shatilo
  • I. A. Antonyuk-Shcheglova
Biogerontology

Abstract

A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.

Key Words

pineal gland peptides epithalamine accelerated aging prevention 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • O. V. Korkushko
    • 1
  • V. Kh. Khavinson
    • 2
  • V. B. Shatilo
    • 1
  • I. A. Antonyuk-Shcheglova
    • 1
  1. 1.Institute of GerontologyAcademy of Medical Sciences of UkraineKiev
  2. 2.St. Petersburg Institute of Bioregulation and GerontologyNorth Western Division of Russian Academy of Medical SciencesRussia

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