Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes

  • E. A. Vladychenskaya
  • O. V. Tyulina
  • A. A. Boldyrev


Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homocysteic acid increased intracellular Ca2+ concentration, activated of protein kinase C, and induced accumulation of reactive oxygen species, which reflected the involvement of homocysteic acid into cell signaling mechanisms.

Key Words

glutamate receptors reactive oxygen species lymphocytes homocysteic acid homocysteine 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • E. A. Vladychenskaya
    • 1
    • 2
  • O. V. Tyulina
    • 2
  • A. A. Boldyrev
    • 1
    • 2
  1. 1.Institute of NeurologyRussian Academy of Medical SciencesRussia
  2. 2.M. V. Lomonosov Moscow State UniversityMoscow

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