Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 6, pp 704–707 | Cite as

Hemodynamic effects of peptide fragments of differentiation factor HLDF

  • D. I. Rzhevskii
  • S. M. Dranitsyna
  • L. K. Baidakova
  • A. N. Myrashev
  • I. A. Kostanyan
Article

Abstract

Hemodynamic activity of peptides from differentiation factor HLDF (promyelocytic HL-60 line) was studied on WKY and SHR-SP rats. Intravenous infusion of the test peptides was accompanied by changes in blood pressure and heart rate, which depended on the structure of peptides and functional activity of the organism and differed in normotensive and hypertensive animals.

Key Words

differentiation factor HLDF hemodynamics rats 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. N. Goncharenko, L. I. Deev, I. A. Kostanyan, et al., Radiats. Biol. Radioekol., 42, No. 2, 164–168 (2002).Google Scholar
  2. 2.
    S. M. Dranitsyna, I. A. Kostanyan, S. G. Andreeva, et al., Bioorg. Khimiya, 26, No. 5, 340–351 (2000).Google Scholar
  3. 3.
    I. A. Kostanyan, M. V. Astapova, E. V. Navolotskaya, et al., Ibid., 26, No. 7, 505–511 (2000).CrossRefGoogle Scholar
  4. 4.
    I. A. Kostanyan, M. V. Astapova, E. V. Starovoytova, et al., Ibid., 21, No. 4, 243–248 (1995).Google Scholar
  5. 5.
    S. V. Litvinova, A. L. Kalyuzhnyi, V. V. Aristova, et al., Ibid., 137, No. 5, 511–514 (2004).Google Scholar
  6. 6.
    S. V. Litvinova, I. A. Kostanyan, V. V. Aristova, et al., Byll. Eksp. Biol. Med., 135, No. 2, 155–157 (2003).Google Scholar
  7. 7.
    T. Backlund, E. Palojoki, A. Saraste, et al., Cardiovasc. Res., 57, No. 3, 727–737 (2003).PubMedCrossRefGoogle Scholar
  8. 8.
    S. Chatterjee, L. T. Bish, V. Jayasankar, et al., J. Thorac. Cardiovasc. Surg., 125, No. 6, 1461–1469 (2003).PubMedCrossRefGoogle Scholar
  9. 9.
    J. M. Hammel, C. A. Caldarone, T. L. Van Natta, et al., Ibid., 125, No. 6, 1268–1275 (2003).PubMedCrossRefGoogle Scholar
  10. 10.
    I. A. Kostanyan, M. V. Astapova, E. V. Starovoytova, et al., FEBS Lett., 356, Nos. 2–3, 327–329 (1994).PubMedCrossRefGoogle Scholar
  11. 11.
    S. Lopez-Ongil, M. Saura, D. Rodriguez-Puyol, et al., Am. J. Physiol., 271, No. 3, Pt. 2, H1072–H1078 (1996).Google Scholar
  12. 12.
    P. Mulder, S. Barbier, C. Monteil, et al., J. Cardiovasc. Pharmacol., 43, No. 4, 489–494 (2004).PubMedCrossRefGoogle Scholar
  13. 13.
    N. Iu. Sakharova, I. A. Kostanian, T. N. Lepikhova, et al., Ontogenez, 33, No. 3, 195–200 (2002).PubMedGoogle Scholar
  14. 14.
    V. V. Sherstnev, Med. Pregl., 57, No. 3–4, 120–124 (2004).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • D. I. Rzhevskii
    • 1
  • S. M. Dranitsyna
    • 2
  • L. K. Baidakova
    • 1
  • A. N. Myrashev
    • 1
  • I. A. Kostanyan
    • 2
  1. 1.Laboratory of Biological Tests, Branch of the M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesPushchino
  2. 2.Laboratory for Proteins of Hormonal RegulationRussia

Personalised recommendations