Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 6, pp 688–690 | Cite as

Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

  • E. V. Mikhal’chik
  • S. M. Titkova
  • M. V. Anurov
  • A. P. Ettinger
  • L. G. Korkina
Article

Abstract

Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content increased in the lungs and epidermis. The preparation of α-tocopherol, selenium aspartate, and ubiquinone abolished the effect of lipopolysaccharide, but did not modulate the increase in chemiluminescence under the influence of this agent.

Key Words

burns lipopolysaccharide chemiluminescence antioxidants 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • E. V. Mikhal’chik
    • 1
  • S. M. Titkova
    • 2
  • M. V. Anurov
    • 2
  • A. P. Ettinger
    • 2
  • L. G. Korkina
    • 1
  1. 1.Department of Molecular BiologyRussian State Medical UniversityMoscow
  2. 2.Department of PhysiologyRussian State Medical UniversityMoscow

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