Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 3, pp 331–333 | Cite as

Antimutagenic characteristics of new diazacrown compounds with N-carboxyalkyl substitutes

  • G. D. Zasukhina
  • I. M. Vasil’eva
  • A. I. Vedernikov
  • S. P. Gromov
  • M. V. Alfimov
Pharmacology and Toxicology

Abstract

Two new benzodiaza-15-crown-5 compounds containing two N-hydroxycarbonylmethyl or N-hydroxycarbonylpropyl substitutes were synthesized. The first of these compounds exhibited more pronounced protective effects towards human cells according to criteria of primary DNA injury and cell survival after exposure to γ-radiation and CdCl2; by antimutagenic activity this compound was comparable to garlic extract. The antimutagenic effect of these compounds was realized not through the antioxidant mechanism.

Key Words

antimutagens antioxidants crown compounds plant extracts 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. V. Alfimov, Vestn. Rossiisk. Akad. Nauk, 73, No. 5, 442–445 (2003).Google Scholar
  2. 2.
    I. M. Vasil’eva and G. D. Zasukhina, Genetika, 38, No. 3, 422–425 (2002).PubMedGoogle Scholar
  3. 3.
    A. D. Durnev, Vestn. Rossiisk. Akad. Med. Nauk, No. 10, 70–76 (2001).Google Scholar
  4. 4.
    G. D. Zasukhina, I. M. Vasil’eva, N. I. Alekhina, et al., Genetika, 39, No. 12, 1630–1633 (2003).PubMedGoogle Scholar
  5. 5.
    G. D. Zasukhina, I. M. Vasil’eva, A. D. Durnev, et al., Dokl. Rossiisk. Akad. Nauk, 384, 560–562 (2002).Google Scholar
  6. 6.
    G. D. Zasukhina, I. M. Vasil’eva, E. S. Mikhal’chik, et al., Byull. Eksp. Biol. Med., 135, 302–305 (2003).Google Scholar
  7. 7.
    G. N. L’vova and G. D. Zasukhina, Genetika, 38, No. 3, 306–309 (2002).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • G. D. Zasukhina
    • 1
  • I. M. Vasil’eva
    • 1
  • A. I. Vedernikov
    • 2
  • S. P. Gromov
    • 2
  • M. V. Alfimov
    • 2
  1. 1.Institute of General GeneticsRussian Academy of SciencesRussia
  2. 2.Center of PhotochemistryRussian Academy of SciencesMoscow

Personalised recommendations