Antimutagenic characteristics of new diazacrown compounds with N-carboxyalkyl substitutes
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Two new benzodiaza-15-crown-5 compounds containing two N-hydroxycarbonylmethyl or N-hydroxycarbonylpropyl substitutes were synthesized. The first of these compounds exhibited more pronounced protective effects towards human cells according to criteria of primary DNA injury and cell survival after exposure to γ-radiation and CdCl2; by antimutagenic activity this compound was comparable to garlic extract. The antimutagenic effect of these compounds was realized not through the antioxidant mechanism.
Key Wordsantimutagens antioxidants crown compounds plant extracts
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- 1.M. V. Alfimov, Vestn. Rossiisk. Akad. Nauk, 73, No. 5, 442–445 (2003).Google Scholar
- 3.A. D. Durnev, Vestn. Rossiisk. Akad. Med. Nauk, No. 10, 70–76 (2001).Google Scholar
- 5.G. D. Zasukhina, I. M. Vasil’eva, A. D. Durnev, et al., Dokl. Rossiisk. Akad. Nauk, 384, 560–562 (2002).Google Scholar
- 6.G. D. Zasukhina, I. M. Vasil’eva, E. S. Mikhal’chik, et al., Byull. Eksp. Biol. Med., 135, 302–305 (2003).Google Scholar