Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 5, pp 644–647 | Cite as

Mechanisms of the Effects of Granulocytic CSF on Tissue Reparation during Chronic CCl4-Induced Damage to the Liver

  • N. V. Sotnikova
  • L. A. Stavrova
  • L. A. Gur'antseva
  • T. Yu. Khrichkova
  • T. I. Fomina
  • N. V. Vetoshkina
  • T. Yu. Dubskaya
  • S. A. Sergeeva
  • O. I. Epshtein
  • L. A. Ermolaeva
  • A. M. Dygai
  • E. D. Gol'dberg
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

Abstract

Hepatoprotective effects of granulocytic CSF were studied using experimental model of CCl4-induced hepatitis. It was found that treatment with granulocytic CSF increased the content of stromal precursors and mesenchymal stem cells in the bone marrow and peripheral blood with subsequent increase in the number of hepatic precursor cells in the liver. These findings attest to mobilization of progenitor mesenchymal cells and their migration into damages liver tissue, which accelerates its regeneration related to changes in the parenchyma, but not connective tissue development.

Key Words

hepatitis granulocyte colony-stimulating factor stem cells 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • N. V. Sotnikova
    • 1
    • 2
  • L. A. Stavrova
    • 1
    • 2
  • L. A. Gur'antseva
    • 1
    • 2
  • T. Yu. Khrichkova
    • 1
    • 2
  • T. I. Fomina
    • 1
    • 2
  • N. V. Vetoshkina
    • 1
    • 2
  • T. Yu. Dubskaya
    • 1
    • 2
  • S. A. Sergeeva
    • 1
    • 2
  • O. I. Epshtein
    • 1
    • 2
  • L. A. Ermolaeva
    • 1
    • 2
  • A. M. Dygai
    • 1
    • 2
  • E. D. Gol'dberg
    • 1
    • 2
  1. 1.Institute of Pharmacology, Tomsk Research CenterRussian Academy of Medical SciencesTomskRussia
  2. 2.Materia-Medika Holding Research-and Production CompanyRussia

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