Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 4, pp 378–380 | Cite as

Estradiol-Dependent Effect of Nitric Oxide on Meiotic Maturation of Mouse Oocytes

Article

Abstract

Estradiol dipropionate decreased the number of oocytes in mouse ovary and suppressed meiotic maturation of these cells. Administration of NO donors sodium nitroprusside and S-nitroso-N-acetylpenicillamine increased the ability of ovarian oocytes to complete meiotic maturation and counteracted the effect of estradiol dipropionate. Our results suggest that estradiol is involved in the regulation of production and release of ovarian NO.

Key Words

NO estradiol mouse oocytes 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of Immunology and Cytotoxic Sera, A. A. Bogomolets Institute of PhysiologyUkrainian Academy of SciencesKievUkraine

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