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Study of Antiparkinsonic Activity of Panavir on a Model of Parkinson Syndrome Induced by Systemic Administration of MPTP to Outbred Rats and C57Bl/6 Mice

  • T. S. Kalinina
  • L. N. Nerobkova
  • T. A. Voronina
  • S. V. Stovbun
  • A. A. Litvin
  • V. I. Sergienko
Pharmacology and Toxicology

Abstract

The effect of panavir on Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was studied in C57Bl/6 mice and outbred albino rats. Two injections of panavir significantly reduced the severity of oligokinesia and autonomic manifestations of experimentally induced Parkinson's syndrome.

Key Words

Parkinson's syndrome MPTP neurotoxin dopamine 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • T. S. Kalinina
    • 1
  • L. N. Nerobkova
    • 1
  • T. A. Voronina
    • 1
  • S. V. Stovbun
    • 2
  • A. A. Litvin
    • 2
  • V. I. Sergienko
    • 2
  1. 1.V. V. Zakusov Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.Institute of Physicochemical MedicineMinistry of Health of the Russian FederationMoscowRussia

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