Bulletin of Experimental Biology and Medicine

, Volume 139, Issue 6, pp 700–702 | Cite as

Bax and Bcl-XL Apoptosis Protein mRNA in Rat Brain Stem and Cortex during Ontogeny

  • A. V. Bannova
  • P. N. Men’shanov
  • F. A. Il’inykh
  • T. S. Kalinina
  • N. N. Dygalo


Bax mRNA level in fetal rat brain stem increases by day 40 of life and then decreases, while level of Bcl-XL mRNA reaches the adult value over one month. Bax mRNA level in the cerebral cortex decreases from day 8 to day 90 of life, while Bcl-XL mRNA level does not change. Judging from Bcl-XL/Bax mRNA ratio, cortical cells exhibit higher readiness to apoptosis than brain stem cells.

Key Words

Bax Bcl-XL brain ontogeny apoptosis 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • A. V. Bannova
    • 1
  • P. N. Men’shanov
    • 1
  • F. A. Il’inykh
    • 1
  • T. S. Kalinina
    • 1
  • N. N. Dygalo
    • 1
  1. 1.Laboratory of Genetic Base of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian DivisionRussian Academy of SciencesNovosibirskRussia

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