Bulletin of Experimental Biology and Medicine

, Volume 139, Issue 2, pp 168–171 | Cite as

Humoral Mechanisms of Regulation of Erhythropoiesis during Hypoxia

  • G. N. Zyuz’kov
  • A. M. Dygai
  • E. D. Gol’dberg
General Pathology and Pathophysiology
Received:

Abstract

We studied the dynamics of erythropoietin content and erythropoietic activity of the serum during hypoxia of different genesis and severity. Our results show that humoral factors play an important role in the regulation of erythropoiesis during oxygen deficiency. Serum erythropoietic activity underwent similar changes in different types of hypoxia associated with similar hematological shifts. A discrepancy was observed between erythropoietic activity and serum erythropoietin concentration.

Key Words

hypoxia erythropoiesis erythropoietic activity erythropoietin 
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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • G. N. Zyuz’kov
    • 1
  • A. M. Dygai
    • 1
  • E. D. Gol’dberg
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research Center, Siberian DivisionRussian Academy of Medical SciencesTomskRussia

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