Bulletin of Experimental Biology and Medicine

, Volume 138, Issue 10, pp 423–424 | Cite as

Comparative study of vasaprostan and alprostan in spontaneous platelet aggregation test in mice

  • D. V. Gol’dshtein
  • E. I. Maevskii
  • V. N. Pogorelova
Methods
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Abstract

We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.

Key Words

Vasaprostan Alprostan SHK mice spontaneous platelet aggregation 
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REFERENCES

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    E. I. Maevskii, A. N. Murashev, O. G. Aksenova, et al., Tromboz, Gemostaz, i Reologiya, No. 4, 41–45 (2002).Google Scholar
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    Fundamentals of Diagnosis of Hemostasis Disorders [in Russian], Moscow (1999).Google Scholar
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    Manual of Experimental (preclinical) Studies of New Drugs [in Russian], Moscow (2000).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • D. V. Gol’dshtein
    • 1
  • E. I. Maevskii
    • 1
  • V. N. Pogorelova
    • 1
  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino.

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