Archives of Sexual Behavior

, Volume 47, Issue 7, pp 2101–2107 | Cite as

Preferences for Injectable PrEP Among Young U.S. Cisgender Men and Transgender Women and Men Who Have Sex with Men

  • Katie B. BielloEmail author
  • Sybil Hosek
  • Morgan T. Drucker
  • Marvin Belzer
  • Matthew J. Mimiaga
  • Elliot Marrow
  • Julia Coffey-Esquivel
  • Jennifer Brothers
  • Kenneth H. Mayer
Original Paper


Young men who have sex with men account for approximately 20% of incident HIV infections in the U.S. Antiretroviral pre-exposure prophylaxis (PrEP) administered as a daily pill has been shown to decrease HIV acquisition in at-risk individuals. New modalities for PrEP are being developed and tested, including injectable PrEP; however, acceptability of these emerging modalities has not yet been examined in youth. We conducted six focus groups with 36 young men and transgender men and women who have sex with men in Boston, Chicago, and Los Angeles in 2016 to assess interest in and preference for different PrEP modalities. Youth were purposively recruited based on diversity of age, race/ethnicity, and prior PrEP experience. Data were coded using content coding based on key domains of the interview guide, in particular around the central themes of interest in and barriers and facilitators to injectable PrEP use. Participants were knowledgeable about oral PrEP but suggested barriers to broader uptake, including stigma, marginalization, and access to information. While participants were split on preference for injectable versus oral PrEP, they agreed quarterly injections may be more manageable and better for those who have adherence difficulties and for those who engage in sex more frequently. Concerns specific to injectable PrEP included: severity/duration of side effects, pain, level of protection prior to next injection, distrust of medical system and injections, and cost. Understanding barriers to and preferences for diverse prevention modalities will allow for more HIV prevention options, improved products, and better interventions, thus allowing individuals to make informed HIV prevention choices.


HIV prevention Pre-exposure prophylaxis Men who have sex with men Transgender Sexual orientation 



This study was supported by Viiv Healthcare, Inc. Additional support for Dr. Mayer’s role was provided by the Harvard University Center for AIDS Research (CFAR), an NIH Funded Program (P30 AI060354), which is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIGMS, NIMHD, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interest to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Katie B. Biello
    • 1
    • 2
    • 3
    • 4
  • Sybil Hosek
    • 5
  • Morgan T. Drucker
    • 3
  • Marvin Belzer
    • 6
  • Matthew J. Mimiaga
    • 1
    • 2
    • 3
    • 4
  • Elliot Marrow
    • 3
  • Julia Coffey-Esquivel
    • 3
  • Jennifer Brothers
    • 5
  • Kenneth H. Mayer
    • 3
    • 7
    • 8
  1. 1.Department of Behavioral and Social SciencesBrown University School of Public HealthProvidenceUSA
  2. 2.Department of EpidemiologyBrown University School of Public HealthProvidenceUSA
  3. 3.The Fenway Institute, Fenway HealthBostonUSA
  4. 4.Center for Health Equity ResearchBrown UniversityProvidenceUSA
  5. 5.Department of PsychiatryStroger Hospital of Cook CountyChicagoUSA
  6. 6.Division of Adolescent MedicineChildren’s Hospital Los AngelesLos AngelesUSA
  7. 7.Division of Infectious DiseasesBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA
  8. 8.Global Health and PopulationHarvard T. H. Chan School of Public HealthBostonUSA

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