Parents’ Perspectives About Adolescent Boys’ Involvement in Biomedical HIV Prevention Research
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Research on the use of pre-exposure prophylaxis (PrEP) among adolescents at high risk for HIV is urgently needed, and parents’ perspectives on these studies are essential for guiding the responsible conduct of adolescent PrEP research. We conducted interviews with 30 parents of adolescent boys (50% known/presumed heterosexual; 50% sexual minority) to understand their views of research risks and benefits and parental permission regarding their son’s involvement in a hypothetical PrEP adherence trial. Parents identified several health and educational benefits of the study and expressed that waiving parental permission would overcome barriers to accessing PrEP, particularly for youth who may benefit most. Among their concerns were medication non-adherence and risk compensation. Parents provided suggestions to facilitate informed, rational, and voluntary participation decisions and protect youth’s safety if parental permission was waived. These findings can inform ways to increase parental trust in PrEP research and create adequate protections for adolescent participants.
KeywordsHIV prevention Pre-exposure prophylaxis Parents Adolescents Men who have sex with men
This study was supported by R01MD009561 from the National Institute on Minority Health and Health Disparities (PIs: Mustanski and Fisher). Brian A. Feinstein's time was supported by a grant from the National Institute on Drug Abuse (1F32DA042708). We acknowledge the NIH supported Third Coast Center for AIDS Research for creating a supportive environment for HIV/AIDS research (P30AI117943). The content in this manuscript is solely the responsibility of the authors and does not reflect the views of the National Institutes of Health. We are grateful to Kai Korpak, Maggie Matson, and Arielle Zimmerman for their assistance with participant recruitment, interview transcription, and coding. We also would like to thank our participants, who generously gave us their time and from whom we learned so much.
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