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Apoptosis

, Volume 25, Issue 1–2, pp 1–11 | Cite as

Influenza A virus-induced apoptosis and virus propagation

  • Patrick B. Ampomah
  • Lina H. K. LimEmail author
Review

Abstract

Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and mortality worldwide. They affect cellular processes such as proliferation, protein synthesis, autophagy, and apoptosis. Although apoptosis is considered an innate cellular response to invading infectious pathogens, IAVs have evolved to encode viral proteins that modulate host cellular apoptosis in ways that support efficient viral replication and propagation. An understanding of the modulation of host responses is essential to the development of novel therapeutics for the treatment of IAV infections. In this review, we discuss the IAV lifecycle, biology, and strategies employed by the virus to modulate apoptosis to enhance viral survival and establish an infection.

Keywords

Influenza virus Apoptosis Cell death Virus propagation Interferons 

Notes

Funding

Funding for this study was provided by grants from the National Medical Research Council in Singapore (NMRC/CBRG/056/2014) awarded to LHKL. PAB was supported by a NUS-SINGA graduate scholarship.

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Authors and Affiliations

  1. 1.Department of Physiology, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore
  2. 2.NUS Immunology Program, Life Sciences InstituteNational University of SingaporeSingaporeSingapore

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