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Apoptosis

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A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

  • Liping Chen
  • Bixia Weng
  • Huimin Li
  • Haonan Wang
  • Qian Li
  • Xiaoyan Wei
  • Hui Deng
  • Sicen Wang
  • Chengxi Jiang
  • Renyu Lin
  • Jianzhang Wu
Article
  • 20 Downloads

Abstract

Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-κB signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.

Keywords

Anti-lung cancer Toxicity Apoptosis Pyroptosis NF-κB 

Notes

Acknowledgements

This work was supported by the Zhejiang Province Natural Science Fund of China (Grant Nos. LY15H280014, LY17H160059, LY19H130001), Technology Foundation for Medical Science of Zhejiang Province (2015KYA1506), the National Natural Science Foundation of China (Grant Nos. 81272462), the Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Chemical Biology Research Center, College of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouChina
  2. 2.Department of Pharmaceutical SciencesTonglu First Peoples HospitalHangzhouChina
  3. 3.Department of Periodontics, Hospital & School of StomatologyWenzhou Medical UniversityWenzhouChina
  4. 4.Department of PharmacyZhejiang Cancer HospitalHangzhouChina
  5. 5.School of PharmacyXi’an Jiaotong UniversityXi’anChina
  6. 6.Department of OtorhinolaryngologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina

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