Apoptosis

, Volume 16, Issue 4, pp 321–333

Conversation between apoptosis and autophagy: “Is it your turn or mine?”

  • Vincenzo Giansanti
  • Alicia Torriglia
  • A. Ivana Scovassi
Original Paper

Abstract

Drug resistance of cancer cells is often correlated with apoptosis evasion; however, an active involvement of autophagy in this scenario has been recently proposed, based on the evidence that autophagy could exert a protective role toward the activation of apoptosis in cancer cells. In this review, we briefly review the basic features of apoptosis, and we describe in details the molecular patterns of autophagy, with a special emphasis on its still controversial physiological function(s). The crucial factors governing the cross talk between autophagy and apoptosis will be illustrated.

Keywords

Apoptosis Autophagy Cancer Cell death 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Vincenzo Giansanti
    • 1
  • Alicia Torriglia
    • 2
    • 3
    • 4
    • 5
  • A. Ivana Scovassi
    • 1
  1. 1.IGM-CNRPaviaItaly
  2. 2.Université Pierre et Marie Curie, UMRS 872ParisFrance
  3. 3.Université Paris Descartes, UMRS 872ParisFrance
  4. 4.Ecole Nationale Vétérinaire d’Alfort, CROVMaisons AlfortFrance
  5. 5.INSERM, Centre de Recherches des Cordeliers, UMRS 872ParisFrance

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