Apoptosis

, Volume 13, Issue 10, pp 1281–1289

The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study

  • Susan Matulevicius
  • Anand Rohatgi
  • Amit Khera
  • Sandeep R. Das
  • Andrew Owens
  • Colby R. Ayers
  • Carlos H. Timaran
  • Eric B. Rosero
  • Mark H. Drazner
  • Ronald M. Peshock
  • James A. de Lemos
Original Paper

DOI: 10.1007/s10495-008-0254-1

Cite this article as:
Matulevicius, S., Rohatgi, A., Khera, A. et al. Apoptosis (2008) 13: 1281. doi:10.1007/s10495-008-0254-1

Abstract

Background

Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis.

Methods

Caspase-3 was measured in 3,221 subjects from the Dallas Heart Study. Electron beam computed tomography measures of coronary calcium (CAC) (n = 2,404) and magnetic resonance imaging (MRI) measures of abdominal aortic wall thickness (AWT) (n = 2,208) and aortic compliance (AC) (n = 2,328) were obtained. Multivariate analyses were performed, adjusting for age, sex, ethnicity, body mass index (BMI), traditional cardiovascular risk factors, and cardiac medications.

Results

In univariable analysis, caspase-3 associated with CAC (P < 0.0001), AWT (P = 0.002), and AC (P < 0.0001). After multivariable adjustment, 4th quartile caspase-3 (compared to 1st quartile) was significantly associated with CAC (P = 0.004), AWT (P = 0.02), and AC (P < 0.0001) with similar findings for caspase-3 as a continuous variable.

Conclusions

Caspase-3 independently associates with CAC, AWT, and AC, suggesting a link between apoptosis and atherosclerosis.

Keywords

Human Apoptosis Atherosclerosis Biological markers Magnetic resonance imaging Tomography  X-ray computed 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Susan Matulevicius
    • 1
  • Anand Rohatgi
    • 1
  • Amit Khera
    • 1
  • Sandeep R. Das
    • 1
  • Andrew Owens
    • 1
  • Colby R. Ayers
    • 1
  • Carlos H. Timaran
    • 2
  • Eric B. Rosero
    • 2
  • Mark H. Drazner
    • 1
  • Ronald M. Peshock
    • 1
  • James A. de Lemos
    • 1
    • 3
  1. 1.Donald W. Reynolds Cardiovascular Clinical Research CenterUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Vascular and Endovascular Surgery DivisionUniversity of Texas Southwestern Medical CenterDallasUSA
  3. 3.University of Texas Southwestern Medical Center at DallasDallasUSA

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