Apoptosis

, Volume 12, Issue 5, pp 869–876

Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?

  • Michal Schwarz
  • Miguel A. Andrade-Navarro
  • Atan Gross
Article

Abstract

Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.

Keywords

Apoptosis Mitochondrial carrier proteins Mitochondrial pores BCL-2 family members BID Mitochondrial carrier homolog 2 (Mtch2) ADP/ATP translocase (ANT) Voltage dependent anion channel (VDAC) 

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Copyright information

© Springer Science + Business Media, LLC 2007

Authors and Affiliations

  • Michal Schwarz
    • 1
  • Miguel A. Andrade-Navarro
    • 2
    • 3
  • Atan Gross
    • 1
  1. 1.Department of Biological RegulationWeizmann Institute of ScienceRehovotIsrael
  2. 2.Ottawa Health Research InstituteOttawaCanada
  3. 3.Faculty of Medicine, Department of Cellular and Molecular MedicineUniversity of OttawaOttawa

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