Apoptosis

, Volume 12, Issue 5, pp 841–855

The permeability transition pore in cell death

Article

Abstract

The permeability transition pore (PT-pore) is a multi-component protein aggregate in mitochondria that comprises factors in the inner as well as in the outer mitochondrial membrane. This complex has two functions: firstly, it regulates the integration of oxidative phosphorylation into the cellular energy household and secondly, it induces cell death when converted into an unspecific channel. The latter causes a collapse of the mitochondrial membrane potential and activates a chain of events that culminate in the demise of the cell. It has been controversial for some time whether the PT-pore is causative for or only amplifies a signal of cell death but novel results confirm a central role of this protein complex for cell death induction. While a considerable body of data exist on its subunit composition, recent genetic knock-out experiments suggest that the identity of the core factors of the PT-pore is still unresolved. Moreover, accumulating evidence point to a much more complex composition of this protein complex than anticipated. Here, we review the current knowledge of its subunit composition, the evidence of a role in cell death, and we propose a model for the activation of the PT-pore for cell death.

Keywords

Apoptosis Mitochondria Phospholipids Cardiolipin Contact sites Membrane structure 

Copyright information

© Springer Science + Business Media, LLC 2007

Authors and Affiliations

  1. 1.Imperial College LondonLondonUK
  2. 2.Faculty of BiologyUniversity of KonstanzKonstanzGermany

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