, Volume 10, Issue 1, pp 5–11 | Cite as

Peripheral survival of naïve CD8+ T cells

  • I. E. Brown
  • M. Mashayekhi
  • M. Markiewicz
  • M.-L. Alegre
  • T. F. GajewskiEmail author


Maintenance of a sufficient population of naïve CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naïve peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.


CD8 naive peripheral survival T cell 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • I. E. Brown
    • 1
  • M. Mashayekhi
    • 2
  • M. Markiewicz
    • 1
  • M.-L. Alegre
    • 2
  • T. F. Gajewski
    • 1
    • 2
    Email author
  1. 1.The Department of PathologyThe University of ChicagoChicagoUSA
  2. 2.Department of MedicineChicagoUSA

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