Apoptosis

, Volume 10, Issue 3, pp 499–502

SOD-1 inhibits FAS expression in cortex of APP transgenic mice

  • Z. Chen
  • R.-S. Duan
  • M. Lepécheur
  • E. Paly
  • J. London
  • J. Zhu
Article

Abstract

Peptides derived from proteolytic processing of the amyloid precursor protein (APP) are important for the pathogenesis of Alzheimer’s disease (AD). In the present study, we found that transgenic mice overexpressing wild-type human APP gene (hAPP/+) displayed a much higher expression of FAS, one of the death receptor subfamily. This FAS overexpression was significantly reduced in the cortex of mice overexpressing both wild-type hAPP gene and wild-type human superoxide dismutase-1 gene (hSOD-1). Moreover hSOD-1 transgenic expression was associated with an increase of Glial fibrillary acidic protein (GFAP) production. This study indicates that SOD-1 overexpression can inhibit FAS expression, which may be beneficial in AD.

Keywords

FAS GFAP hAPP hSOD-1 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Z. Chen
    • 1
  • R.-S. Duan
    • 1
  • M. Lepécheur
    • 2
  • E. Paly
    • 2
  • J. London
    • 2
  • J. Zhu
    • 1
    • 3
    • 4
  1. 1.Division of Experimental Geriatrics, Department of Neurotec, Karolinska InstituteHuddinge University HospitalStockholmSweden
  2. 2.Paris CedexFrance
  3. 3.Department of Neurology, The first HospitalJiLin UniversityChangchunChina
  4. 4.Division of Geriatric Medicine (B84), Karolinska InstituteHuddinge University HospitalStockholmSweden

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