Apoptosis

, Volume 10, Issue 3, pp 459–469

Gap junctions and the propagation of cell survival and cell death signals

  • D. V. Krysko
  • L. Leybaert
  • P. Vandenabeele
  • K. D’Herde
Article

Abstract

Gap junctions are a unique type of intercellular channels that connect the cytoplasm of adjoining cells. Each gap junction channel is comprised of two hemichannels or connexons and each connexon is formed by the aggregation of six protein subunits known as connexins. Gap junction channels allow the intercellular passage of small (< 1.5 kDa) molecules and regulate essential processes during development and differentiation. However, their role in cell survival and cell death is poorly understood. We review experimental data that support the hypothesis that gap junction channels may propagate cell death and survival modulating signals. In addition, we explore the hypothesis that hemichannels (or unapposed connexons) might be used as a paracrine conduit to spread factors that modulate the fate of the surrounding cells. Finally, direct signal transduction activity of connexins in cell death and survival pathways is addressed.

Keywords

apoptosis gap junctions survival chemichannels connexins 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • D. V. Krysko
    • 1
    • 2
    • 4
  • L. Leybaert
    • 3
  • P. Vandenabeele
    • 2
  • K. D’Herde
    • 1
  1. 1.Department of Human Anatomy, Embryology, Histology and Medical PhysicsGhent UniversityGhentBelgium
  2. 2.Molecular Signaling and Cell Death Unit, Department of Molecular Biomedical Research, VIBGhent UniversityGhentBelgium
  3. 3.Department of Physiology and PathophysiologyGhent UniversityGhentBelgium
  4. 4.Department of Human Anatomy, Embryology, Histology and Medical PhysicsGhentBelgium

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