Applied Psychophysiology and Biofeedback

, Volume 35, Issue 1, pp 39–61

Functional Neuroanatomy and the Rationale for Using EEG Biofeedback for Clients with Asperger’s Syndrome

Article

Abstract

This paper reviews the symptoms of Asperger’s Syndrome (AS), a disorder along the autism continuum, and highlights research findings with an emphasis on brain differences. Existing theories concerning AS are described, including theory of mind (Hill and Frith in Phil Trans Royal Soc Lond, Bull 358:281–289, 2003), mirror neuron system (Ramachandran and Oberman in Sci Am 295(5):62–69, 2006), and Porges’ (Ann N Y Acad Sci 1008:31–47, 2003, The neurobiology of autism, Johns Hopkins University Press, Baltimore, 2004) polyvagal theory. (A second paper, Outcomes using EEG Biofeedback Training in Clients with Asperger’s Syndrome, summarizes clinical outcomes obtained with more than 150 clients.) Patterns seen with QEEG assessment are then presented. Single channel assessment at the vertex (CZ) reveals patterns similar to those found in Attention-Deficit/Hyperactivity Disorder. Using 19-channel data, significant differences (z-scores > 2) were found in the amplitude of both slow waves (excess theta and/or alpha) and fast waves (beta) at various locations. Differences from the norm were most often found in mirror neuron areas (frontal, temporal and temporal-parietal). There were also differences in coherence patterns, as compared to a normative database (Neuroguide). Low Resolution Electromagnetic Tomography Analysis (Pascual-Marqui et al. in Methods Find Exp Clin Pharmacol 24C:91–95, 2002) suggested the source of the abnormal activity was most often the anterior cingulate. Other areas involved included the amygdala, uncus, insula, hippocampal gyrus, parahippocampal gyrus, fusiform gyrus, and the orbito-frontal and/or ventromedial areas of the prefrontal cortex. Correspondence between symptoms and the functions of the areas found to have abnormalities is evident and those observations are used to develop a rationale for using EEG biofeedback, called neurofeedback (NFB), intervention. NFB training is targeted to improve symptoms that include difficulty reading and mirroring emotions, poor attention to the outside world, poor self-regulation skills, and anxiety. Porges’ polyvagal theory is used to emphasize the need to integrate NFB with biofeedback (BFB), particularly heart rate variability training. We term this emerging understanding the Systems Theory of Neural Synergy. The name underscores the fact that NFB and BFB influence dynamic circuits and emphasizes that, no matter where we enter the nervous system with an intervention, it will seek its own new balance and equilibrium.

Keywords

Asperger’s Neurofeedback QEEG EEG biofeedback Anterior cingulate Mirror neurons Polyvagal theory Systems theory of neural synergy 

References

  1. Abu-Akel, A. (2003). A neurobiological mapping of theory of mind. Brain Research Reviews, 43, 39–40.Google Scholar
  2. Adolphs, R. (2003). Is the human amygdala specialized for processing social information? Annals of the New York Academy of Sciences, 985, 326.PubMedGoogle Scholar
  3. Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005). A mechanism for impaired fear recognition after amygdala damage. Nature, 433, 68.PubMedGoogle Scholar
  4. Alvarez, A. (2004). Issues in assessment: Asperger’s syndrome and personality. In M. Rhode & T. Klauber (Eds.), The many faces of Asperger’s syndrome. The Tavistock clinic series (pp. 113–128). London: Karnac Books.Google Scholar
  5. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders—4th edition—Text revision. Washington, DC: American Psychiatric Association.Google Scholar
  6. Asperger, H. (1944). Die―"Autistischen Psychopathen" im Kindesalter. Archiv fuer Psychiatrie und Nervenkrankheiten, 117, 76–136. English translation (1991) Autistic psychopathy in childhood. In U. Frith (Editor and Translator) Autism and Asperger’s syndrome (pp. 37–92). Cambridge, United Kingdom: Cambridge University Press.Google Scholar
  7. Attwood, T. (1997). Asperger’s syndrome: A Guide for parents and professionals. London: Jessica Kingsley Publications.Google Scholar
  8. Attwood, T. (2007). The complete guide to Asperger’s syndrome. London: Jessica Kingsley Publishers.Google Scholar
  9. Bachevalier, J., & Loveland, K. A. (2006). The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism. Neuroscience and Behavioral Reviews, 30, 97–117.Google Scholar
  10. Bara, B. G., Bucciarelli, M., & Colle, L. (2001). Communicative abilities in autism: Evidence for attentional deficits. Brain and Language, 77(2), 216–240.PubMedGoogle Scholar
  11. Barton, J. S., Cherkasov, M. V., Hefter, R., Cox, T. A., O’Connor, M., & Manoach, D. S. (2004). Are patients with social developmental disorders prosopagnosic? Perceptual heterogeneity in the Asperger and socio-emotional processing disorders. Brain, 127(8), 1706–1716.PubMedGoogle Scholar
  12. Bashe, P. R., & Kirby, B. (2005). The OASIS guide to Asperger syndrome. New York: Crown Publishers.Google Scholar
  13. Belmonte, M. K., & Yurgelun-Todd, D. A. (2003). Functional anatomy of impaired selective attention and compensatory processing in autism. Cognitive Brain Research, 17(3), 651–664.PubMedGoogle Scholar
  14. Blandford, S. (2005). Children can learn with their shoes off: Supporting students with Asperger’s syndrome in mainstream schools and colleges. Educational Psychology in Practice, 21(1), 76–78.Google Scholar
  15. Bleuler, E. (1911). Dementia praecox oder gruppe der schizophrenien. J. Zinken translation, 1950. New York: International University Press.Google Scholar
  16. Bowler, D. M., Gardiner, J. M., & Berthollier, N. (2004). Source memory in adolescents and adults with Asperger’s syndrome. Journal of Autism and Developmental Disorders, 34(5), 533–542.PubMedGoogle Scholar
  17. Bregman, J. D. (2005). Definitions and characteristics of the spectrum. In D. Zager (Ed.), Autism spectrum disorders: Identification, education, and treatment (3rd ed., pp. 3–46). Mahwah: Lawrence Erlbaum Associates.Google Scholar
  18. Carothers, D. E., & Taylor, R. L. (2004). Social cognitive processing in elementary school children with Asperger syndrome. Education & Training in Developmental Disabilities, 39(2), 177–187.Google Scholar
  19. Carr, L., Iacoboni, M., Dubeau, M. C., & Mazziotta, J. C. (2003). Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences, USA, 100, 5497–5502.Google Scholar
  20. Chan, A. S., Sze, S. L., & Cheung, M. (2007). Quantitative electroencephalographic profiles for children with autistic spectrum disorder. Neuropsychology, 21(1), 74–81.PubMedGoogle Scholar
  21. Channon, S. (2004). Frontal lobe dysfunction and everyday problem-solving: Social and non-social contributions. Acta Psychologica, 115(2–3), 235–254.PubMedGoogle Scholar
  22. CNS Response. (2008). www.cnsresponse.com.
  23. Coben, R. (2005). Assessment guided neurofeedback for autistic spectrum disorder. Presentation at the Society for Neuronal Regulation 13th annual conference, Denver, Colorado.Google Scholar
  24. Coben, R. (2006). Panel on autistic spectrum disorders at the 36th annual meeting of the Association for Applied Psychophysiology and Biofeedback. Portland, OR.Google Scholar
  25. Coben, R. (2007). Connectivity-guided neurofeedback for autistic spectrum disorder. Biofeedback, 35(4), 131–135.Google Scholar
  26. Committee on Children with Disabilities. (2001). Technical report: The pediatrician’s role in the diagnosis and management of autistic spectrum disorders in children. Pediatrics, 107(5), 1–35.Google Scholar
  27. Corbett, B. A., & Constantine, L. J. (2006). Autism and attention deficit hyperactivity disorder: Assessing attention and response control with the integrated visual and auditory continuous performance test. Child Neuropsychology, 12(4–5), 335–348.PubMedGoogle Scholar
  28. Cumine, V., Leach, J., & Stevenson, G. (1998). Asperger syndrome: A practical guide for teachers. London: David Fulton Publishers.Google Scholar
  29. Dalton, K., Nacewicz, B., Johnstone, T., Schaefer, H., Gernsbacher, M., Goldsmith, H., et al. (2005). Gaze fixation and the neural circuitry of face processing in autism. Nature Neuroscience, 8(4), 519–526.PubMedGoogle Scholar
  30. Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., et al. (2006). Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience, 9(1), 28–30.PubMedGoogle Scholar
  31. Deruelle, C., Rondan, C., Gepner, B., & Tardif, C. (2004). Spatial frequency and face processing in children with autism and Asperger syndrome. Journal of Autism and Developmental Disorders, 34(2), 199–210.PubMedGoogle Scholar
  32. Devinsky, O., Morrell, M., & Vogt, B. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118, 279–306.PubMedGoogle Scholar
  33. Dissanayake, C., & Macintosh, K. (2003). Mind reading and social functioning in children with autistic disorder and Asperger’s disorder. In B. Repacholi & V. Slaughter (Eds.), Individual differences in theory of mind: Implications for typical and atypical development. Macquarie monographs in cognitive science (pp. 213–239). New York: Psychology Press.Google Scholar
  34. Ehlers, S., & Gillberg, C. (1993). The epidemiology of Asperger’s syndrome: A total population study. Journal of Child Psychology and Psychiatry, 34(8), 1327–1350.PubMedGoogle Scholar
  35. Emerich, D. M., Creaghead, N. A., Grether, S. M., Murray, D., & Grasha, C. (2003). The comprehension of humorous materials by adolescents with high-functioning autism and Asperger’s syndrome. Journal of Autism and Developmental Disorders, 33(3), 253–257.PubMedGoogle Scholar
  36. Fisch, B. (1999). Fisch and Spehlmann’s EEG primer: Basic principles of digital and analog EEG-third edition. New York: Elsevier.Google Scholar
  37. Fitzgerald, M. (2000). Jonathan swift: Victim of Asperger’s syndrome? The Canadian Journal of Diagnosis, 2000, 31–36.Google Scholar
  38. Fitzgerald, M. (2004). Response to “Features of Alexithymia or features of Asperger’s syndrome?” by M. Corcos. European Child & Adolescent Psychiatry, 13(2), 123.Google Scholar
  39. Fitzgerald, M., & Kewley, G. (2005). Attention-deficit/hyperactivity disorder and Asperger’s syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 44(3), 210.PubMedGoogle Scholar
  40. Frith, U. (1991). (Editor and Translator) Autism and Asperger’s syndrome. Cambridge, United Kingdom: Cambridge University Press.Google Scholar
  41. Frombonne, E., & Tidmarsh, L. (2003). Epidemiological data on Asperger disorder. Child & Adolescent Psychiatric Clinics of North America, 12(1), 15–21.Google Scholar
  42. Gattegno, M. P., & De Fenoyl, C. (2004). Social abilities training in people with Asperger syndrome/L’entraînement aux habiletés sociales chez les personnes attients du syndrome d’Asperger. Journal de Thérapie Comportementale et Cognitive, 14(3), 109–115.Google Scholar
  43. Gevirtz, R. (2007). Biofeedback training to increase heart rate variability. In P. M. Lehrer, R. L. Woolfolk, & W. E. Sime (Eds.), Principles and practice of stress management (3rd ed.). New York: Guilford Publications.Google Scholar
  44. Gevirtz, R., & Lehrer, P. (2005). Resonant frequency heart rate biofeedback. In M. S. Schwartz & F. Andrasik (Eds.), Biofeedback a practitioner’s guide-third edition. New York: Guilford Press.Google Scholar
  45. Ghaziuddin, M., & Mountain-Kimchi, K. (2004). Defining the intellectual profile of Asperger syndrome: Comparison with high-functioning autism. Journal of Autism & Developmental Disorders. 34(3), 279-284.Google Scholar
  46. Gillberg, C. (1989). Asperger syndrome in 23 Swedish children. Developmental Medicine and Child Neurology, 31, 520–531.PubMedGoogle Scholar
  47. Gillberg, C. (1991). Clinical and neurobiological aspects of Asperger’s syndrome in six families studied. In U. Frith (Ed.), Autism and Asperger’s syndrome (pp. 122–145). Cambridge, UK: Cambridge University Press.Google Scholar
  48. Goodenough-Harris Drawing Test. (1963). The psychological corporation.Google Scholar
  49. Green, V. A., Pituch, K. A., Itchon, J., Choi, A., O’Reilly, M., & Sigafoos, J. (2006). Internet survey of treatments used by parents of children with autism. Research in Developmental Disabilities, 27, 70–84.PubMedGoogle Scholar
  50. Haddon, M. (2002). The curious incident of the dog in the night-time. Toronto: Doubleday Canada.Google Scholar
  51. Hadjikhani, N., Joseph, R. M., Snyder, J., & Tager-Flusberg, H. (2006). Anatomical differences in the mirror neuron system and social cognition network in autism. Cerebral Cortex, 16, 1276–1282.PubMedGoogle Scholar
  52. Hill, E. L., & Frith, U. (2003). Understanding Autism: Insights from mind and brain. Theme Issue ‘Autism: mind and brain. Philosophical Transactions of The Royal Society London, Bulletin 358, 281–289.Google Scholar
  53. Iacoboni, M., & Dapretto, M. (2006). The mirror neuron system and the consequences of its dysfunction. Nature Reviews and Neuroscience, December, 2006, 942–951.Google Scholar
  54. Jantzen, T., Graap, K., Stephanson, S., Marshall, W., & Fitzsimmons, G. (1995). Differences in baseline EEG measures for ADD and normally achieving pre-adolescent males. Biofeedback and Self Regulation, 20(1), 65–82.Google Scholar
  55. Jarusiewicz, E. (2002). Efficacy of neurofeedback for children in the autistic spectrum: A pilot study. Journal of Neurotherapy, 6(4), 39–49.Google Scholar
  56. Jasper, H. (1858). Report of the committee on methods of clinical examination in electroencephalography. EEG and Clinical Neurophysiology, 10, 374.Google Scholar
  57. Johnstone, J., Gunkelman, J., & Lunt, J. (2005). Clinical database development: Characterization of EEG phenotypes. Clinical EEG and Neuroscience, 36(2), 99–107.PubMedGoogle Scholar
  58. Kaland, N., Moller-Nielsen, A., Smith, L., Mortensen, E. L., Callesen, K., & Gottlieb, D. (2005). The strange stories test: A replication study of children and adolescents with Asperger syndrome. European Child and Adolescent Psychiatry, 14(2), 73–82.PubMedGoogle Scholar
  59. Khouzam, H. R., El-Gabalawi, F., Pirwani, N., & Priest, F. (2004). Asperger’s disorder: A review of its diagnosis and treatment. Comprehensive Psychiatry, 45(3), 184–191.PubMedGoogle Scholar
  60. Kleinhans, N., Akshoomoff, N., & Delis, D. C. (2005). Executive functions in autism and Asperger’s disorder: Flexibility, fluency, and inhibition. Developmental Neuropsychology, 27(3), 379–401.PubMedGoogle Scholar
  61. Klin, A., & Miller, K. (2004). When Asperger’s syndrome and a nonverbal learning disability look alike. In M. T. Stein (Ed.), Journal of Developmental & Behavioral Pediatrics. Special Issue: Challenging Cases in Developmental & Behavioral Pediatrics, 25(5S), S59–S64. (This reprinted article originally appeared in the Journal of Developmental & Behavioral Pediatrics, 25(3), 190–195).Google Scholar
  62. Klin, A., Volkmar, & Sparrow, (2000). Asperger’s syndrome. New York: Guilford Press.Google Scholar
  63. Knezevic, B. (2007). Pilot project to ascertain utility of tower of London test (ToL) to assess outcomes of neurofeedback in clients with Asperger’s syndrome. Student Award paper presented at International Society for Neurofeedback and Research, Annual Meeting, San Diego, CA.Google Scholar
  64. Landry, R., & Bryson, S. E. (2004). Impaired disengagement of attention in young children with autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45(6), 1115–1122.Google Scholar
  65. Laurent, A. C., & Rubin, E. (2004). Challenges in emotional regulation in Asperger syndrome and high-functioning autism. Topics in Language Disorders, 24(4), 286–297.Google Scholar
  66. Lawson, J., Baron-Cohen, S., & Wheelwright, S. (2004). Empathizing and systemizing in adults with and without Asperger syndrome. Journal of Autism and Developmental Disorders, 34(3), 301–310.PubMedGoogle Scholar
  67. Linden, M. (2006). Panel on autistic spectrum disorders at the 36th annual meeting of the Association for Applied Psychophysiology and Biofeedback. Portland, OR.Google Scholar
  68. Linden, M., Habib, T., & Radojevic, V. (1996). A controlled study of EEG biofeedback effects on cognitive and behavioral measures with attention-deficit disorder and learning disabled children. Biofeedback and Self-Reguation, 21(1), 35–49.Google Scholar
  69. Loffler, D. (2005). Asperger syndrome: What teachers need to know. Educational Psychology in Practice, 21(1), 80–81.Google Scholar
  70. Lubar, J. F. (1991). Discourse on the development of EEG diagnostics and biofeedback treatment for attention deficit/hyperactivity disorders. Biofeedback and Self-Regulation, 16(3), 202–225.Google Scholar
  71. Lubar, J. F., & Lubar, J. (1984). Electroencephalographic biofeedback of SMR and beta for treatment of attention deficit disorder in a clinical setting. Biofeedback and Self Regulation, 9(1), 1–23.PubMedGoogle Scholar
  72. Lubar, J. F., Swartwood, M. O., Swartwood, J. N., & O’Donnell, P. (1995). Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in T.O.V.A. scores, behavioral ratings, and WISC-R performance. Biofeedback and Self Regulation, 20(1), 83–99.PubMedGoogle Scholar
  73. Macintosh, K. E., & Dissanayake, C. (2004). Annotation: The similarities and differences between autistic disorder and Asperger’s disorder: A review of the empirical evidence. Journal of Child Psychology and Psychiatry, 45(3), 421–434.PubMedGoogle Scholar
  74. Mann, C. A., Lubar, J. F., Zimmerman, A. W., Miller, C. A., & Muenchen, R. A. (1992). Quantitative analysis of EEG in boys with attention-deficit/hyperactivity disorder: Controlled study with clinical implications. Pediatric Neurology, 8(1), 30–36.PubMedGoogle Scholar
  75. Martinez, Y. (2003). Unpublished thesis done as part of the requirements for an Honours B.A. degree. Copy on file at the ADD Centre, Toronto.Google Scholar
  76. Mayes, S. D., & Calhoun, S. L. (2004). Influence of IQ and age in childhood autism: Lack of support for DSM-IV Asperger’s disorder. Journal of Developmental & Physical Disabilities, 16(3), 257–272.Google Scholar
  77. McAlonan, G. M., Cheung, V., Cheung, C., Suckling, J., Lam, G. Y., Tai, K. S., et al. (2005). Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain: Journal of Neurology, 128(2), 268–276.Google Scholar
  78. McCann, J. (2006). Reeg—the new image of diagnostic accuracy. Neuropsychiatry May 7(8).Google Scholar
  79. Meltzoff, A., & Prinz, W. (Eds.). (2002). The imitative mind: Development, evolution and brain bases. New York: Cambridge University Press.Google Scholar
  80. Monastra, V. J. (2005). Electroencephalographic biofeedback (neurotherapy) as a treatment for attention deficit hyperactivity disorder: Rationale and empirical foundation. Child and Adolescent Psychiatric Clinics of North America, 14(1), 55–82.PubMedGoogle Scholar
  81. Monastra, V. J., Lubar, J. F., & Linden, M. (2001). The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: Reliability and validity studies. Neuropsychology, 15(1), 136–144.PubMedGoogle Scholar
  82. Monastra, V. J., Lubar, J. F., Linden, M., VanDeusen, P., Green, G., Wing, W., et al. (1999). Assessing attention deficit hyperactivity disorder via quantitative electroencephalography: An initial validation study. Neuropsychology, 13(3), 424–433.PubMedGoogle Scholar
  83. Monastra, V. J., Monastra, D., & George, S. (2002). The effects of stimulant therapy, EEG biofeedback and parenting on primary symptoms of ADHD. Applied Psychophysiology and Biofeedback, 27(4), 250–272.Google Scholar
  84. Nacewicz, B. M., Dalton, K. M., Johnstone, T., Long, M. T., McAuliff, E. M., Oakes, T. R., et al. (2006). Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. Archives of General Psychiatry, 63(12), 1417–1428.PubMedGoogle Scholar
  85. Nash, J. M. (2002). The secrets of Autism. Time. May 6, 2002/159(18), 36–46.Google Scholar
  86. Neuroguide Delux, 2.3.7. (2007). Robert Thatcher, applied neuroscience Inc. (www.appliedneuroscience.com).
  87. Nikolaenko, N. N. (2004). Metaphorical and associative thinking in healthy children and in children with Asperger’s syndrome at different ages. Human Physiology, 30(5), 532–536.Google Scholar
  88. Nishitani, N., Avikainen, S., & Hari, R. (2004). Abnorml imitation-related cortical activation sequences in Asperger’s syndrome. Annals of Neurology, 55, 558–562.PubMedGoogle Scholar
  89. Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altschuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005). EEG evidence for motor neuron dysfunction in autistic spectrum disorders. Brain Research & Cognitive Brain Research, 24, 190–198.PubMedGoogle Scholar
  90. Pascual-Marqui, R. D., Esslen, M., Kochi, K., & Lehmann, D. (2002). Functional imaging with low resolution electromagnetic tomography (LORETA): A review. Methods and Findings in Experimental and Clinical Pharmacology, 24C, 91–95.Google Scholar
  91. Pfeiffer, H., Iacoboni, M., Mazziotta, C., & Dapretto, M. (2005). Mirror neuron system activity in children and its relation to empathy and interpersonal competence. In Abstract Viewer/Itinerary Planner. Society of Neuroscience Abstract 660(24). Google Scholar
  92. Porges, S. W. (2003). Social engagement and attachment: A phylogenetic perspective. Annals of the New York Academy of Sciences, 1008, 31–47.PubMedGoogle Scholar
  93. Porges, S. W. (2004). The Vagus: A mediator of behavioral and physiologic features associated with autism. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism (pp. 65–78). Baltimore: Johns Hopkins University Press.Google Scholar
  94. Porges, S. W. (2007). The Polyvagal perspective. Biological Psychiatry, 74, 116–143.Google Scholar
  95. Portway, S. M., & Johnson, B. (2005). Do you know I have Asperger’s syndrome? Risks of non-obvious disability. Health, Risk & Society, 7(1), 73–83.Google Scholar
  96. Prichep, E. S., Mas, F., Hollander, E., Liebowitz, M., John, E. R., Almas, M., et al. (1993). Quantitative electroencephalographic subtyping of obsessive-compulsive disorder. Psychiatry Research: Neuroimaging, 50, 25–32.PubMedGoogle Scholar
  97. Ramachandran, V. S., & Oberman, L. M. (2006). Broken mirrors. Scientific American, 295(5), 62–69.PubMedCrossRefGoogle Scholar
  98. Reid, A. (2005). Autistic spectrum disorders: Assessment and intervention results after neurofeedback in 146 cases. Student Award Presentation, International Society for Neuronal Regulation annual meeting. Denver, Colorado.Google Scholar
  99. Ross, E. D. (1981). The aprosodias: Functional-anatomic organization of the affective components of language in the right hemisphere. Archives of Neurology, 38, 561–569.PubMedGoogle Scholar
  100. Rossiter, T. R., & LaVaque, T. J. (1995). A comparison of EEG biofeedbaclk and psychostimulants in treating attention deficit hyperactivity disorders. Journal of Neurotherapy, 1(1), 48–59.Google Scholar
  101. Rourke, B., & Tsatsanis, K. (2000). Nonverbal learning disabilities and Asperger’s syndrome. In A. Klin, F. Volkmar, & S. Sparrow (Eds.), Asperger syndrome. New York: Guilford Press.Google Scholar
  102. Rubin, E., & Lennon, L. (2004). Challenges in social communication in Asperger Syndrome and High-Functioning Autism. Topics in Language Disorders, 24(4), 271–285.CrossRefGoogle Scholar
  103. Salmond, C. H., Ashburner, J., Connelly, A., Friston, K. J., Gadian, D. G., & Vargha-Khadem, F. (2005). The role of the medial temporal lobe in autistic spectrum disorders. European Journal of Neuroscienc, 22(3), 764–772.Google Scholar
  104. Sears, W., & Thompson, L. (1998). The A.D.D. book: New understandings, new approaches to parenting your child. New York: Little, Brown and Co.Google Scholar
  105. Shamay-Tsoory, S. G., Tomer, R., Berger, B. D., Goldsher, D., & Aharon-Peretz, J. (2005). Impaired “Affective Theory of Mind” is associated with right ventromedial prefrontal damage. Cognitive & Behavioral Neurology, 18(1), 55–67.Google Scholar
  106. Shouse, M. N., & Lubar, J. F. (1979). Sensorimotor rhythm (SMR) operant conditioning and methylphenidate in the treatment of hyperkinesis. Biofeedback & Self-Regulation, 4, 299–311.Google Scholar
  107. Simpson, D. (2004). Asperger’s syndrome and autism: Distinct syndromes with important similarities. In M. Rhode & T. Klauber (Eds.), The many faces of Asperger’s syndrome. The Tavistock clinic series (Vol xviii, 302, pp. 25–38). London, England: Karnac Books.Google Scholar
  108. Sloman, L. (2005). Medication use in children with high functioning pervasive developmental disorder and Asperger syndrome. In K. Stoddart (Ed.), Children, youth and adults with Asperger syndrome: Integrating multiple perspectives. London: Jessica Kingsley Publishers.Google Scholar
  109. Soderstrom, H., Nilsson, T., Sjodin, A., Carlstedt, A., & Forsman, A. (2005). The childhood-onset neuropsychiatric background to adulthood psychopathic traits and personality disorders. Comprehensive Psychiatry, 46(2), 111–116.PubMedGoogle Scholar
  110. Solnick, B. (2005). Effects of electroencephalogram biofeedback with Asperger’s syndrome. International Journal of Rehabilitation Research, 28(2), 159–163.Google Scholar
  111. Sterman, M. B. (1999). Atlas of Topometric clinical displays: Functional interpretations and neurofeedback strategied. New Jersey: Sterman-Kaiser Imaging Laboratory.Google Scholar
  112. Sterman, M. B. (2000a). Basic concepts and clinical findings in the treatment of seizure disorders with EEG operant conditioning. Clinical Electroencephalography, 31(1), 45–55.PubMedGoogle Scholar
  113. Sterman, M. B. (2000b). EEG markers for attention deficit disorder: Pharmacological and neurofeedback applications. Child Study Journal, 30(1), 1–22.Google Scholar
  114. Stewart, K. (1998). Helping a child with nonverbal learning disorder or Asperger’s syndrome. Place: Publisher.Google Scholar
  115. Suffin, S. C., & Emory, W. H. (1995). Neurometric subgroups in attentional and affective disorders and their association with pharmacotherapeutic outcomes. Clinical Electroencephalography, 26(2), 76–83.PubMedGoogle Scholar
  116. Swanson, J. M., McBurnett, K., Wigal, T., Pfiffner, L. J., Williams, L., Christian, D. L., et al. (1993). The effect of stimulant medication on children with attention deficit disorder: A “Review of Reviews”. Exceptional Children, 60(2), 154–162.Google Scholar
  117. Tammet, D. (2007). Born on a blue day. London: Free Press (Division of Simon & Shuster).Google Scholar
  118. Tanguay, P. B. (2001). Nonverbal learning disabilities at home: A parent’s guide. London: Jessica Kingsley Publishers.Google Scholar
  119. Thatcher, R. W., Walker, R. A., Biver, C. J., North, D. N., & Curtin, R. (2003). Quantitative EEG normative databases: Validation and clinical correlation. In J. F. Lubar (Ed.), Quantitative electroencephalographic analysis (QEEG) databases for neurotherapy: Description, validation, and application. New York: Haworth Press.Google Scholar
  120. Thompson, M. G. G., & Havelkova, M. (1983). Childhood Psychosis. In P. Steinhauer & Q. Rae-Grant (Eds.), Psychological Problems of the Child in the Family. New York: Basic Books, Inc.Google Scholar
  121. Thompson L., & Thompson M. (1995). Exceptional Results with Exceptional Children. In Proceedings of the Society for the Study of Neuronal Regulation. Annual Meeting: Scottsdale, Arizona.Google Scholar
  122. Thompson, L., & Thompson, M. (1998). Neurofeedback combined with training in metacognitive strategies: Effectiveness in students with ADD. Applied Psychophysiology and Biofeedback, 23(4), 243–263.PubMedGoogle Scholar
  123. Thompson, L., & Thompson, M. (2003a). The neurofeedback book. Wheatridge, CO: Association for Applied Psychophysiology and Biofeedback.Google Scholar
  124. Thompson, M. & Thompson, L. (2003b). Neurofeedback for Asperger’s syndrome: Theoretical rationale and clinical results. The Newsletter of the Biofeedback Society of California, 19(1).Google Scholar
  125. Thompson, L., & Thompson, M. (2006a). Panel on Autistic Spectrum Disorders. 36th Annual meeting of the Association for Applied Psychophysiology and Biofeedback, Portland, Oregon, April.Google Scholar
  126. Thompson, M., & Thompson, L. (2006b). Improving attention in adults and children: Differing electroencephalograhy profiles and implications for training. Biofeedback Magazine, 34(3), 99–105.Google Scholar
  127. Thompson, L., & Thompson, M. (2007a). Autistic spectrum disorders including Asperger’s syndrome: EEG and QEEG findings, results, and neurophysiological rationale for success using neurofeedback training. Presented at the 11th Annual Meeting of the Biofeedback Foundation of Europe, Berlin, Germany. Abstract reprinted in Applied Psychophysiology and Biofeedback, 32(3–4), 213–214.Google Scholar
  128. Thompson, M., & Thompson, L. (2007b). Neurofeedback for stress management. In P. Lehrer, R. Woolfolk, & W. Sime (Eds.), Principles and practice of stress management (3rd ed.). New York: Guilford Publications.Google Scholar
  129. Thompson, M., Thompson, L., & Reid, A. (2008). Neurofeedback outcomes in clients with Asperger’s syndrome. Submitted to Journal of Applied Psychophysiology and Biofeedback.Google Scholar
  130. Thompson, M., & Thompson, L. (2009). Asperger’s syndrome intervention: Combining neurofeedback, biofeedback and metacognition. In T. Budzinski, H. Budzinski, J. Evans, & A. Abarbanel (Eds.), Introduction to quantitative EEG and neurofeedback (2nd ed.). New York: Elsevier.Google Scholar
  131. Tower of London Test. (1982). Colorado assessment tests. www.catstests.com/prod03.htm .
  132. Von Bertalanffy, L. (1976). General systems theory: Foundations, development, applications. New York: George Braziller, Inc.Google Scholar
  133. Weimer, A. K., Schatz, A. M., Lincoln, A., Ballantyne, A. O., & Truaner, D. A. (2001). “Motor” impairment in Asperger syndrome: Evidence for a deficit in proprioception. Journal of Developmental and Behavioral Pediatrics, 22(2), 92–101.PubMedGoogle Scholar
  134. Weitz, P., & Weitz, C. (2002). “About a Boy”. Movie starring Hugh Grant, Universal pictures, Tribeca/working title production.Google Scholar
  135. Wing, L. (1981). Asperger’s syndrome: A clinical account. Psychological Medicine, 11, 115–129.PubMedGoogle Scholar
  136. Wing, L. (2001). The autistic spectrum: A parent’s guide to understanding and helping your child. Berkeley, CA: Ulysses Press.Google Scholar
  137. Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. Journal of Autism and Developmental Disorders, 9, 11–29.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.ADD CentreMississaugaCanada

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