A Pilot Study on the Effects of Heart Rate Variability Biofeedback in Patients with Depression and in Healthy Subjects
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Decreased vagal activity and increased sympathetic arousal have been proposed as major contributors to the increased risk of cardiovascular mortality in patients with depression. It was aim of the present study to assess the feasibility of using heart rate variability (HRV) biofeedback to treat moderate to severe depression. This was an open-label study in which 14 patients with different degrees of depression (13 f, 1 m) aged 30 years (18–47; median; range) and 12 healthy volunteers attended 6 sessions of HRV biofeedback over two weeks. Another 12 healthy subjects were observed under an active control condition. At follow up BDI was found significantly decreased (BDI 6; 2–20; median 25%–75% quartile) as compared to baseline conditions (BDI 22;15–29) in patients with depression. In addition, depressed patients had reduced anxiety, decreased heart rate and increased HRV after conduction of biofeedback (p < 0.05). By contrast, no changes were noted in healthy subjects receiving biofeedback nor in normal controls. In conclusion, HRV biofeedback appears to be a useful adjunct for the treatment of depression, associated with increases in HRV.
KeywordsHeart rate variability biofeedback Effects Depression Healthy subjects Pilot study
The present work was part of a thesis. The authors are sincerely thankful to Mrs. E. Hempel, for her assistance in conducting the study.
- Bennaroch, E. E. (Ed.). (1997). Central autonomic network: functional organization and clinical correlations. Armonck, NY: Futura Publishing Company, Inc.Google Scholar
- Catipovic-Veselica, K., Galic, A., Jelik, K., et al. (2007). Relation between major and minor depression and heart rate, heart-rate variability, and clinical characteristics of patients with acute coronary syndrome. Psychological Reports, 100(3 Pt2), 1245–1254. doi:10.2466/PR0.100.3.1245-1254.PubMedCrossRefGoogle Scholar
- Glassman, A. H., Bigger, J. T., Gaffney, M., & Van Zyl, L. T. (2007). Heart rate variability in acute coronary syndrome patients with major depression: influence of sertraline and mood improvement. Archives of General Psychiatry, 64(9), 1025–1031. doi:10.1001/archpsyc.64.9.1025.PubMedCrossRefGoogle Scholar
- Mück-Weymann, M. (2002). Die Variabilität der Herzschlagfolge - Ein globaler Indikator für Adaptivität in bio-psycho-sozialen Funktionskreisen. Praxis Klinische Verhaltensmedizin und Rehabilitation, 60, 324–330.Google Scholar
- Mück-Weymann, M., & Beise, R. (2005). Herzkohärenztraining – eine moderne Form der Stressbewältigung. Forum Stressmedizin, I, 1–5.Google Scholar
- Mück-Weymann, M., Loew, T., & Hager, D. (1996). Multiparametrisches Bio-Monitoring mit einem computerunterstützten System für psychophysiologische Diagnostik, psychophysiologisch gesteuerte Therapie und Biofeedback. Psycho, 5, 378–384.Google Scholar
- Mück-Weymann, M., Moesler, T., Joraschky, P., Rebensburg, M., & Agelink, M. W. (2002). Depression modulates autonomic cardiac control: A psyhopsychophysiological pathway linking depression and mortality? German Journal of Psychiatry, 5, 67–69.Google Scholar
- Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (Eds.). (1970). State-trait anxiety inventory, manual for the state-trait anxiety inventory. Palo Alto, CA: Consulting Psychologist Press.Google Scholar