Applied Psychophysiology and Biofeedback

, Volume 32, Issue 1, pp 19–30 | Cite as

Preliminary Results of an Open Label Study of Heart Rate Variability Biofeedback for the Treatment of Major Depression

  • Maria Katsamanis KaravidasEmail author
  • Paul M. Lehrer
  • Evgeny Vaschillo
  • Bronya Vaschillo
  • Humberto Marin
  • Steven Buyske
  • Igor Malinovsky
  • Diane Radvanski
  • Afton Hassett
Original Paper


Major depressive disorder (MDD) is a common mood disorder that can result in significant discomfort as well as interpersonal and functional disability. A growing body of research indicates that autonomic function is altered in depression, as evidenced by impaired baroreflex sensitivity, changes in heart rate, and reduced heart rate variability (HRV). Decreased vagal activity and increased sympathetic arousal have been proposed as major contributors to the increased risk of cardiovascular mortality in participants with MDD, and baroreflex gain is decreased. Study objectives: To assess the feasibility of using HRV biofeedback to treat major depression. Design: This was an open-label study in which all eleven participants received the treatment condition. Participants attended 10 weekly sessions. Questionnaires and physiological data were collected in an orientation (baseline) session and Treatment Sessions 1, 4, 7 and 10. Measurements and results: Significant improvements were noted in the Hamilton Depression Scale (HAM-D) and the Beck Depression Inventory (BDI-II) by Session 4, with concurrent increases in SDNN, standard deviation of normal cardiac interbeat intervals) an electrocardiographic estimate of overall measure of adaptability. SDNN decreased to baseline levels at the end of treatment and at follow-up, but clinically and statistically significant improvement in depression persisted. Main effects for task and session occurred for low frequency range (LF) and SDNN. Increases in these variables also occurred during breathing at one’s resonant frequency, which targets baroreflex function and vagus nerve activity, showing that subjects performed the task correctly Conclusions: HRV biofeedback appears to be a useful adjunctive treatment for the treatment of MDD, associated with large acute increases in HRV and some chronic increases, suggesting increased cardiovagal activity. It is possible that regular exercise of homeostatic reflexes helps depression even when changes in baseline HRV are smaller. A randomized controlled trial is warranted.


Vagus nerve Depression Heart rate variability Biofeedback Breathing 



These authors wish to thank Erin Arnold for her help in data analysis; and the Department of Psychiatry at the University of Medicine and Dentistry and NIH P20 MH074634 support (Multiple Unexplained Physical Symptoms in Primary Care Research Center).


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Maria Katsamanis Karavidas
    • 1
    Email author
  • Paul M. Lehrer
    • 1
  • Evgeny Vaschillo
    • 2
  • Bronya Vaschillo
    • 2
  • Humberto Marin
    • 1
  • Steven Buyske
    • 3
  • Igor Malinovsky
    • 2
  • Diane Radvanski
    • 4
  • Afton Hassett
    • 4
  1. 1.Department of PsychiatryUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA
  2. 2.Rutgers University, Center of Alcohol StudiesUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA
  3. 3.Department of StatisticsRutgers UniversityPiscatawayUSA
  4. 4.Department of RheumatologyUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA

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