Antonie van Leeuwenhoek

, Volume 103, Issue 5, pp 947–961 | Cite as

Cyanobacteria: potential candidates for drug discovery

Review Paper

Abstract

Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.

Keywords

Bioactive molecules Anticancerous Antiviral Antimicrobial Clinical trials Extraction methods 

Notes

Acknowledgments

Authors are thankful to Director, CSIR-NBRI for all the facilities and constant encouragement. Rakhi Bajpai Dixit is grateful to Department of Science and Technology (DST, New Delhi), for providing financial assistance in the form of a project (Ref. No. SR/FT/LS-111/2010).

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Algology SectionCSIR-National Botanical Research InstituteLucknowIndia

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