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Antonie van Leeuwenhoek

, Volume 92, Issue 1, pp 95–100 | Cite as

Synergistic bactericidal activity of Eremanthus erythropappus oil or β-bisabolene with ampicillin against Staphylococcus aureus

  • Andréa M. A. NascimentoEmail author
  • Maria G. L. Brandão
  • Gabriel B. Oliveira
  • Isabel C. P. Fortes
  • Edmar Chartone-Souza
Original Paper

Abstract

The activity of Eremanthus erythropappus oil (EO) and some of its compounds and their potential synergistic interaction with ampicillin against different strains of Staphylococcus aureus were investigated. Determination of chemical composition of EO by gas chromatography-mass spectrometry (GC/MS) and bioguided chemical fractionation led to the identification of β-bisabolene as the main active compound. A synergistic bactericidal activity of EO or β-bisabolene with ampicillin against Staphylococcus aureus was observed in a time-kill assay. EO and β- bisabolene have the potential to restore the effectiveness of ampicillin against resistant S. aureus.

Keywords

Eremanthuserythropappus Eremanthus erythropappus oil β-bisabolene Staphylococcus aureus Ampicillin Synergism 

Abbreviations

EO

Eremanthus erythropappus oil

MHB

Mueller-Hinton broth

Notes

Acknowledgements

The authors are indebted to Givaudan Roure do Basil (São Paulo, Brazil) for supplying the authentic volatile compounds. This work was supported by a FAPEMIG grant CBB-1106/03.

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Andréa M. A. Nascimento
    • 1
    Email author
  • Maria G. L. Brandão
    • 2
  • Gabriel B. Oliveira
    • 1
  • Isabel C. P. Fortes
    • 3
  • Edmar Chartone-Souza
    • 1
  1. 1.Departamento de Biologia GeralInstituto de Ciências Biológicas – Universidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Departamento de Produtos Farmacêuticos, Faculdade de FarmáciaUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Departamento de QuímicaInstituto de Ciências Exatas. Universidade Federal de Minas GeraisBelo HorizonteBrazil

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