Annals of Operations Research

, Volume 148, Issue 1, pp 227–250 | Cite as

Electroencephalogram (EEG) time series classification: Applications in epilepsy

  • Wanpracha Art Chaovalitwongse
  • Oleg A. Prokopyev
  • Panos M. Pardalos
Article

Abstract

Epilepsy is among the most common brain disorders. Approximately 25–30% of epilepsy patients remain unresponsive to anti-epileptic drug treatment, which is the standard therapy for epilepsy. In this study, we apply optimization-based data mining techniques to classify the brain's normal and epilepsy activity using intracranial electroencephalogram (EEG), which is a tool for evaluating the physiological state of the brain. A statistical cross validation and support vector machines were implemented to classify the brain's normal and abnormal activities. The results of this study indicate that it may be possible to design and develop efficient seizure warning algorithms for diagnostic and therapeutic purposes.

Keywords

Classification EEG Brain dynamics Optimization Epilepsy Support vector machines 

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References

  1. Begley, C., J. Annegers, D. Lairson, T. Reynolds, and W. Hauser. (1994). “Cost of Epilepsy in the United States: A Model Based on Incidence and Prognosis.” Epilepsia, 35(6), 1230–1243.CrossRefGoogle Scholar
  2. Begley, C., M. Famulari, J. Annegers, D. Lairson, T. Reynolds, S. Coan, S. Dubinsky, M. Newmark, C. Leibson, E. So, and W. Rocca. (2000). “The Cost of Epilepsy in the United States: An Estimate from Population-Based Clinical and Survey Data.” Epilepsia, 41(3), 342–351.CrossRefGoogle Scholar
  3. Chaovalitwongse, W., P. Pardalos, L. Iasemidis, D.-S. Shiau, and J. Sackellares. (2003). “Applications of Global Optimization and Dynamical Systems to Prediction of Epileptic Seizures.” In P. Pardalos, J. Sackellares, L. Iasemidis, and P. Carney, (Eds). Quantitative Neuroscience, pp. 1–36. Kluwer.Google Scholar
  4. Chaovalitwongse, W., P. Pardalos and O. Prokoyev. (2004). “A New Linearization Technique for Multi-quadratic 0–1 Programming Problems.” Operations Research Letters, 32(6), 517–522.CrossRefGoogle Scholar
  5. Elger, C. and K. Lehnertz. (1998). “Seizure Prediction by Non-Linear Time Series Analysis of Brain Electrical Activity.” European Journal of Neuroscience, 10, 786–789.Google Scholar
  6. Iasemidis, L. (1991). “On the Dynamics of the Human Brain in Temporal Lobe Epilepsy.” PhD thesis, University of Michigan, Ann Arbor.Google Scholar
  7. Iasemidis, L., P. Pardalos, J. Sackellares, and D.-S. Shiau. (2001). “Quadratic Binary Programming and Dynamical System Approach to Determine the Predictability of Epileptic Seizures.” Journal of Combinatorial Optimization, 5, 9–26.CrossRefGoogle Scholar
  8. Iasemidis, L. and J. Sackellares. (1991). “The Evolution with Time of the Spatial Distribution of the Largest Lyapunov Exponent on the Human Epileptic Cortex.” In D. Duke and W. Pritchard (Eds.), Measuring Chaos in the Human Brain, pp. 49–82. World Scientific.Google Scholar
  9. Iasemidis, L., D.-S. Shiau, W. Chaovalitwongse, J. Sackellares, P. Pardalos, P. Carney, J. Principe, A. Prasad, B. Veeramani, and K. Tsakalis. (2003).“Adaptive Epileptic Seizure Prediction System.” IEEE Transactions on Biomedical Engineering, 5(5), 616–627.Google Scholar
  10. Lehnertz, K. and C. Elger. (1998). “Can Epileptic Seizures be Predicted? Evidence from Nonlinear Time Series Analysis of Brain Electrical Activity.” Phys. Rev. Lett., 80, 5019–5022.Google Scholar
  11. Litt, B., R. Esteller, J. Echauz, D. Maryann, R. Shor, T. Henry, P. Pennell, C. Epstein, R. Bakay, M. Dichter, and G. Vachtservanos. (2001). “Epileptic Seizures May Begin Hours in Advance of Clinical Onset: A Report of Five Patients.” Neuron, 30, 51–64.Google Scholar
  12. Martinerie, J., C.V. Adam, and M.L.V. Quyen. (1998). “Epileptic Seizures Can Be Anticipated by Non-Linear Analysis.” Nature Medicine, 4, 1173–1176.CrossRefGoogle Scholar
  13. Pardalos, P., W. Chaovalitwongse, L. Iasemidis, J. Sackellares, D.-S. Shiau, P. Carney, O. Prokopyev, and V. Yatsenko. (2004). “Seizure Warning Algorithm Based on Spatiotemporal Dynamics of Intracranial Eeg.” Mathematical Programming, 101(2), 365–385.CrossRefGoogle Scholar
  14. Pardalos, P., V. Yatsenko, J. Sackellares, D.-S. Shiau, W. Chaovalitwongse, and L. Iasemidis. (2003). “Analysis of EEG Data Using Optimization, Statistics, and Dynamical System Techniques.” Computational Statistics & Data Analysis, 44(1–2), 391–408.Google Scholar
  15. Quyen, M. L.V., J. Martinerie, M. Baulac, and F. Varela. (1999). “Anticipating Epileptic Seizures in Real Time by Non-Linear Analysis of Similarity Between EEG Recordings.” NeuroReport, 10, 2149–2155.CrossRefGoogle Scholar
  16. Wolf, A., J. Swift, H. Swinney, and J. Vastano. (1985). “Determining Lyapunov Exponents from a Time Series.” Physica D, 16, 285–317.Google Scholar

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Wanpracha Art Chaovalitwongse
    • 1
  • Oleg A. Prokopyev
    • 2
  • Panos M. Pardalos
    • 2
  1. 1.Department of Industrial and Systems EngineeringRutgers UniversityPiscatawayUSA
  2. 2.Department of Industrial and Systems EngineeringUniversity of FloridaGainesvilleUSA

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