Multifactorial inheritance with selection
We present an alternative model for multifactorial inheritance. By changing the way the malformation (and selection) is determined from the genetic information, we arrive at a model that can be properly handled in the mathematical sense. This includes the proof of population convergence and computation of conditional malformation probabilities in a closed form. We also present a comparison to similar models and results of fitting our model to Hungarian data.
Key words and phrasesmultifactorial inheritance birth defect balance of selection and mutation
Mathematics Subject Classification62P10 92D25
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- E. Czeizel and G. Tusnády, Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary, Akadémiai Kiadó (Budapest, 1984). Google Scholar
- K. Sankaranarayanan, N. Yasuda, R. Chakraborty, G. Tusnády and A. Czeizel, Ionizing radiation and genetic risks. V. Multifactorial diseases: A review of epidemiological and genetic aspects of congenital abnormalities in man and of models on maintenance of quantitative traits in populations, Mutat. Res., Rev. Genet. Toxicol., 317 (1994), 1–23. CrossRefGoogle Scholar
- G. Tusnády, Mutation and selection, Magy. Tud., 7 (1997), 792–805 (in Hungarian). Google Scholar