Analog Integrated Circuits and Signal Processing

, Volume 98, Issue 2, pp 233–241 | Cite as

A novel high CMRR trans-impedance instrumentation amplifier for biomedical applications

  • Rajasekhar Nagulapalli
  • Khaled Hayatleh
  • Steve Barker
  • Saddam Zourob
  • Nabil YassineEmail author
  • Sumathi Raparthy
  • Amr Tammam


A compact high gain current mode instrumentation amplifier (IA) has been proposed for biomedical imaging applications. Conventional IAs rely on several matching resistors which occupies a lot of silicon area, the input and output common mode voltages are exactly same and the maximum applied signal amplitude is limited by internal node voltage swings. The present proposal eliminates the need for matching resistors by processing signals in the current mode. Hence input amplitudes are no longer limited by the voltage headroom and input and output common-mode voltages can be independent. An amplifier with a differential gain greater than 52 dB and a common mode rejection ratio greater than 120 dB has been implemented in 65 nm CMOS Technology and Post layout simulations were presented. The total circuit occupies 4500 μm2 silicon area and circuit consumes ~ 260 μA from 1.8 V power supply.


CMRR Low power CMOS Trans-impedance 



The authors acknowledge and would like to thank Dr Bryan Hart for his valuable time and advice on the writing of this paper.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Engineering, Computing and Mathematics, Faculty of Technology, Design and EnvironmentOxford Brookes UniversityWheatleyUK

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