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Distribution of distances between topologies and its effect on detection of phylogenetic recombination

  • Leonardo de Oliveira MartinsEmail author
  • Hirohisa Kishino
Article

Abstract

Inferences about the evolutionary history of biological sequence data are greatly influenced by the presence of recombination, that tends to disrupt the phylogenetic signal. Current recombination detection procedures focus on the phylogenetic disagreement of the data along the aligned sequences, but only recently the link between the quantification of this disagreement and the strength of the recombination was realised. We previously described a hierarchical Bayesian procedure based on the distance between topologies of neighbouring sites and a Poisson-like prior for these distances. Here, we confirm the improvement provided by this topology distance and its prior over existing methods that neglect this information by analysing datasets simulated under a complex evolutionary model. We also show how to obtain a mosaic structure representative of the posterior sample based on a newly developed centroid method.

Keywords

Viral recombination SPR distance Markov chain Monte Carlo Phylogenetics 

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Copyright information

© The Institute of Statistical Mathematics, Tokyo 2009

Authors and Affiliations

  • Leonardo de Oliveira Martins
    • 1
    Email author
  • Hirohisa Kishino
    • 2
  1. 1.Department of Biochemistry, Genetics and Immunology, Faculty of BiologyUniversity of VigoVigoSpain
  2. 2.Graduate School of Agriculture and Life SciencesUniversity of TokyoTokyoJapan

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