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HIV Prevalence Among Tuberculosis Patients in Sub-Saharan Africa: A Systematic Review and Meta-analysis

  • Yalemzewod Assefa GelawEmail author
  • Gail Williams
  • Ricardo J. Soares Magalhães
  • Charles F. Gilks
  • Yibeltal Assefa
Original Paper

Abstract

HIV associated tuberculosis (TB) morbidity and mortality is a major concern in sub-Saharan Africa. Understanding the level of HIV infection among TB patients is vital for adequate response. We conducted a systematic review and meta-analysis to estimate the prevalence of HIV in TB patients in sub-Saharan Africa. We searched PubMed, EMBASE, Web of Science and CINAHL databases. A meta-analysis with a random-effects model was performed. Potential sources of heterogeneity in the prevalence estimates were explored using meta-regression analysis. We identified 68 studies that collectively included 62,969 TB patients between 1990 and 2017. The overall estimate of HIV prevalence in TB patients was 31.8% (95% CI 27.8–36.1). There was substantial heterogeneity in the prevalence estimates in Southern, Central, Eastern, and Western sub-Saharan Africa regions (43.7, 41.3, 31.1 and 25.5%, respectively). We noted an apparent reduction in the estimate from 33.7% (95% CI 27.6–40.4) in the period before 2000 to 25.7% (95% CI 17.6–336.6) in the period after 2010. The Eastern and Southern sub-Saharan Africa region had higher prevalence [34.4% (95% CI 29.3–34.4)] than the Western and Central region [27.3% (95% CI 21.6–33.8)]. The prevalence of HIV in TB patients has declined over time in sub-Saharan Africa. We argue that this is due to strengthened HIV prevention and control response and enhanced TB/HIV collaborative activities. Countries and regions with high burdens of HIV and TB should strengthen and sustain efforts in order to achieve the goal of ending both HIV and TB epidemics in line with the Sustainable Development Goals.

Keywords

HIV TB Prevalence Sub-Saharan Africa Meta-analysis 

Notes

Acknowledgements

YG is supported by University of Queensland International Scholarship (UQI). We thank Mr. Scott Macintyre for his professional support during electronic database search.

Author Contribution

YAG, YA, GW and RSM conceived the research question and study design. YAG performed the electronic database search, data abstraction, analysis and wrote the first draft of the article. YAG supervised and reviewed the database search, data analysis and interpretation. GW, CG, RSM and HG supervised the research process and provided comments. All authors reviewed subsequent versions and approved the final version of the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

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Supplementary material 1 (DOCX 18 kb)
10461_2018_2386_MOESM2_ESM.docx (24 kb)
Supplementary material 2 (DOCX 24 kb)

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Authors and Affiliations

  1. 1.School of Public Health, Faculty of MedicineThe University of QueenslandBrisbaneAustralia
  2. 2.Institute of Public Health, College of Medicine and Health ScienceUniversity of GondarGondarEthiopia
  3. 3.UQ Spatial Epidemiology Laboratory, Faculty of Science, School of Veterinary ScienceThe University of QueenslandGattonAustralia
  4. 4.Children’s Health and Environment Program, Faculty of Medicine, Child Health Research CentreThe University of QueenslandBrisbaneAustralia

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