Factors Associated with Mood Disorder Diagnosis Among a Population Based Cohort of Men and Women Living With and Without HIV in British Columbia Between 1998 and 2012
Using data from the Comparison of Outcomes and Service Utilization Trends (COAST) study we examined factors associated with mood disorder diagnosis (MDD) among people living with HIV (PLHIV) and HIV-negative individuals in British Columbia, Canada. MDD cases were identified between 1998 and 2012 using International Classification of Disease 9 and 10 codes. A total of 491,796 individuals were included and 1552 (23.7%) and 60,097 (12.4%) cases of MDD were identified among the HIV-positive and HIV-negative populations, respectively. Results showed HIV status was associated with greater odds of MDD among men and lower odds among women. Among PLHIV, MDD was significantly associated with: identifying as gay, bisexual or other men who have sex with men compared to heterosexuals; higher viral load; history of injection drug use; and concurrent anxiety, dysthymia, and substance use disorders. Findings highlight the need for comprehensive and holistic HIV and mental health care.
KeywordsHIV Mood disorders Canada Mental health
Study concept and design: K.C., C.O., S. K., D. M. S., O.E., J. S.G. M. & R.S.H. Statistical Analysis: C. F-V. & S. J. Drafting of the manuscript was conducted by K. C., C. O, S.K. & D. M. S., with critical revisions from all authors. The principal investigator (R.S.H.) takes responsibility for the integrity and accuracy of the data, and has the final decision in the submission of the manuscript. In addition, we would like to thank Dr. Jeannie Shoveller, Dr. Kate Salters and other COAST team members and support staff for ongoing support and feedback during the preparation of this manuscript. The authors would like to thank the COAST study participants, the BC Centre for Excellence in HIV/AIDS, the BC Ministry of Health, and the institutional data stewards for granting access to the data, and Population Data BC for facilitating the data linkage process. The COAST study members and investigators include: Rolando Barrios, Guillaume Colley, Oghenowede Eyawo, Nada Gataric, Richard Harrigan, Robert Hogg (PI), Mark Hull, Scott Lear, Viviane Dias Lima, Julio Montaner, David Moore, Bohdan Nosyk, Jeannie Shoveller, Danielle Smith, Sam Wiseman, and David Whitehurst.
All inferences, opinions, and conclusions drawn from this manuscript are those of the authors and do not reflect the opinions or policies of the Data Stewards or the funders.
Compliance with Ethical Standards
Conflicts of interest
RSH has received funding from Canadian Institutes of Health, through a Foundation Award, to support this research study; RSH has held grant funding in the last 10 years from the National Institutes of Health, Canadian Institutes of Health Research, Health Canada, Merck, and the Social Sciences and Humanities Research Council of Canada. JSGM is supported with grants paid to his institution, from Abbvie, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, and Viiv Healthcare.
Ethical approval was obtained from the University of British Columbia/Providence Health Care (#H09-02905) and Simon Fraser University (#2013s0566) research ethics boards.
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