AIDS and Behavior

, Volume 20, Issue 8, pp 1675–1681 | Cite as

Pilot Randomized Trial of Collaborative Behavioral Treatment for Chronic Pain and Depression in Persons Living with HIV/AIDS

  • Lisa A. UebelackerEmail author
  • Risa B. Weisberg
  • Debra S. Herman
  • Genie L. Bailey
  • Megan M. Pinkston-Camp
  • Sarah L. Garnaat
  • Michael D. Stein
Brief Report


In this pilot study, we assessed feasibility and acceptability of a behavior therapy intervention for pain and depressive symptoms in persons living with HIV/AIDS (PLWH). We randomly assigned 23 participants to HIV-PASS (HIV-Pain and Sadness Study) or a health education control arm for 3 months. On average, participants attended more than 5 sessions (of 7 possible) in both arms. Qualitative data suggest HIV-PASS participants understood key messages and made concrete behavioral changes. HIV-PASS was associated with effects in the expected direction for three of four outcomes, including the primary outcome (pain-related interference with functioning). Findings suggest that HIV-PASS is promising.


HIV/AIDS Chronic pain Depression Behavioral medicine 



Research reported in this publication was supported by the National Institute of Nursing Research of the National Institutes of Health under Award Number R21NR013438 to Drs. Uebelacker and Stein. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Compliance with Ethical Standards

Conflict of Interest

Dr. Bailey’s institution has received grant support from Titan Pharmaceuticals, Inc., Alkermes, Inc., BioDelivery Sciences International, Inc., Orexo, Braeburn Pharmaceuticals and Indivior Inc. Dr. Bailey has received travel support from Titan Pharmaceuticals, Inc. and BioDelivery Sciences International, Inc. and is on the advisory boards of Braeburn Pharmaceuticals, BioDelivery Sciences International, Inc. and Camurus AB. The other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Lisa A. Uebelacker
    • 1
    • 2
    Email author
  • Risa B. Weisberg
    • 2
    • 3
  • Debra S. Herman
    • 1
    • 2
  • Genie L. Bailey
    • 2
    • 4
  • Megan M. Pinkston-Camp
    • 2
    • 5
  • Sarah L. Garnaat
    • 1
    • 2
  • Michael D. Stein
    • 2
    • 5
  1. 1.Butler HospitalProvidenceUSA
  2. 2.Alpert Medical School of Brown UniversityProvidenceUSA
  3. 3.Boston VA Healthcare SystemBostonUSA
  4. 4.Stanley Street Treatment and ResourcesFall RiverUSA
  5. 5.The Miriam HospitalProvidenceUSA

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