The Effect of a Community-Based Exercise Program on Inflammation, Metabolic Risk, and Fitness Levels Among Persons Living with HIV/AIDS
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The human immunodeficiency virus (HIV) pandemic remains a top national health priority. Chronic inflammation may be a critical component in the disease course of HIV as C-reactive protein (CRP) is elevated and associated with increased mortality. This study examined the effect of 3 months of combined aerobic and resistance exercise training among a diverse cohort of HIV-infected men and women. The fixed effect of time for CRP was found to be non-significant (F[1,57.3] = 1.7, p = 0.19). There was a significant fixed effect for time for upper body (F[1,51.6] = 18.1, p < 0.05) and lower body strength (F[1,48.0] = 15.7, p < 0.05) and significant declines in diastolic blood pressure (p = 0.002) and waist circumference (p = 0.027). Though levels of CRP were not impacted after 3 months training, participants demonstrated a significant increase in muscular strength as well as beneficial changes in metabolic risk factors. Future studies should focus on determining the optimal exercise intervention length and mode to reduce inflammation among individuals living with HIV.
KeywordsHuman immunodeficiency virus Aerobic exercise Resistance training C-reactive protein Inflammation Metabolic risk
This material is based on work supported by AstraZeneca HealthCare Foundation’s Connections for Cardiovascular HealthSM (CCH) program. The CCH program funds charitable work, not research that addresses cardiovascular health issues within the United States and its territories. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and have not been reviewed for approval by the AstraZeneca HealthCare Foundation.
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