Risk Factors for HIV Acquisition in High Risk Women in a Generalised Epidemic Setting
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In South Africa young women bear a disproportionate burden of HIV infection however, risk factors for HIV acquisition are not fully understood in this setting. In a cohort of 245 women, we used proportional hazard regression analysis to examine the association of demographic, clinical and behavioural characteristics with HIV acquisition. The overall HIV incidence rate (IR) was 7.20 per 100 women years (wy), 95 % confidence interval (CI) 4.50–9.80. Women 18–24 years had the highest HIV incidence (IR 13.20 per 100 wy, 95 % CI 6.59–23.62) and were almost three times more likely to acquire HIV compared to women 25 years and older [adjusted Hazard Ratio (aHR) 2.61, 95 % CI 1.05–6.47]. Similarly, women in relationships with multiple sex partners had more than twice the risk of acquiring HIV when compared to women who had no partner or who had a husband or stable partner (aHR 2.47, 95 % CI 0.98–6.26). HIV prevention programmes must address young women’s vulnerability and sex partner reduction in this setting.
KeywordsRisk factors HIV acquisition Women
This work was supported by grants from the Comprehensive International Program of Research on AIDS (CIPRA) of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), US Department of Health and Human Services (DHHS) [Grant number 5U19 AI051794] and the National Research Foundation, South Africa [Grant number UID 67385]. NN was partially sponsored by the University of KwaZulu-Natal for career development.The authors would like to acknowledge the CAPRISA 002 Study Team and the participants of the CAPRISA 002 Study without whom this work would not have been possible.
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