Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders
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Depression and apathy are common among people living with HIV (PLWH). However, in PLWH, it is unclear whether depression and apathy are distinct conditions, which contribute to different patterns of disruption to cognitive processing and brain systems. Understanding these conditions may enable the development of prognostic indicators for HIV associated neurocognitive disorders (HAND). The present study examined substance use behavior and cognitive deficits, associated with depression and apathy, in 120 PLWH, using hierarchical regression analyses. Higher levels of depression were associated with a history of alcohol dependence and greater deficits in processing speed, motor and global cognitive functioning. Higher levels of apathy were associated with a history of cocaine dependence. It is recommended that PLWH get screened appropriately for apathy and depression, in order to receive the appropriate treatment, considering the comorbidities associated with each condition. Future research should examine the neurological correlates of apathy and depression in PLWH.
KeywordsHIV Depression Apathy Substance Cognition
This work was supported by the National Institutes of Health (Grants R01MH074368 and P01AA019072), and the Lifespan/Tufts/Brown Center for AIDS Research (Grant P30AI042853). This research has been facilitated by the infrastructure and resources provided by the Brown University Center for Alcohol and Addiction Studies, the Lifespan/Tufts/Brown Center for AIDS Research and The Miriam Hospital Immunology Center.
Conflict of interest
The authors have declared that no conflicts of interest exist.
- 8.Association AP. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Publishing; 2013.Google Scholar
- 23.Shapiro ME, Mahoney JR, Peyser D, Zingman BS, Verghese J. Cognitive Reserve Protects Against Apathy in Individuals with Human Immunodeficiency Virus. Arch Clin Neuropsychol. 2013;29(1):110–20.Google Scholar
- 33.Grace J, Malloy P, Psychological Assessment Resources I. FrSBe, Frontal Systems Behavior Scale: Professional Manual: Psychological Assessment Resources; 2001.Google Scholar
- 36.Brandt J, Benedict RHB. Hopkins verbal learning test-revised (HVLT-R). Lutz: Psychological Assessment Resources, Inc.; 1991.Google Scholar
- 37.Benedict RHB. Brief Visuospatial Memory Test-Revised. Odessa: Psychological Assessment Resources; 1997.Google Scholar
- 38.Benton AL, Hamsher K, Sivan AB. Multilingual aphasia examination. Iowa City: AJA Associates; 1994.Google Scholar
- 39.Golden CJ. Stroop color and word test. Chicago: Stoelting; 1978.Google Scholar
- 40.Reitan RM. Trail Making Test. Tucson: Reitan Neuropsychology Laboratory; 1992.Google Scholar
- 41.Kløve H. Grooved Pegboard. Lafeyette: Lafeyette Instruments; 1963.Google Scholar
- 42.Wechsler D. Wechsler Adult Intelligence Scale-III (WAIS-III). San Antonio: The Psychological Corporation; 1997.Google Scholar
- 44.Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17(1):3–16.PubMedCentralPubMedCrossRefGoogle Scholar
- 46.Heaton RK, Taylor MJ, Grant I. Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults. Lutz: Psychological Assessment Resources; 2004.Google Scholar
- 51.Poudel-Tandukar K, Bertone-Johnson ER, Palmer PH, Poudel KC. C-reactive protein and depression in persons with Human Immunodeficiency Virus infection. Brain Beha Immun. 2014.Google Scholar