Barriers to Medication Adherence in Behaviorally and Perinatally Infected Youth Living with HIV
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The study explored barriers to antiretroviral medication adherence in perinatally and behaviorally HIV infected adolescents and young adults in a cross-sectional, multisite sample. The study included a subset of a convenience sample from a cross-sectional analysis. Participants were youth with HIV ages 12–24 who were prescribed HIV medication and reported missing medication in the past 7 days (n = 484, 28.4 % of protocol sample). The top barriers were similar for perinatally and behaviorally infected youth, but perinatally infected youth reported significantly more barriers. Forgetting, not feeling like taking medication and not wanting to be reminded of HIV infection were the most common barriers reported. Number of barriers was significantly correlated with percent of doses missed, viral load, and psychological distress for perinatally infected youth and with doses missed, psychological distress, and substance use for behaviorally infected youth. Interventions to improve adherence to HIV medications should not only address forgetfulness and choosing not to take medications, but also consider route of infection.
KeywordsAntiretroviral medication adherence Route of infection Barriers to adherence Youth living with HIV Intervention development
The Adolescent Trials Network for HIV/AIDS Interventions is funded by grants 5 U01 HD 40533 and 5 U01 HD 40474 from the National Institutes of Health through the National Institute of Child Health and Human Development (Bill Kapogiannis and Carol Worrell) with supplemental funding from the National Institute on Drug Abuse (Nicolette Borek), the National Institute of Mental Health (Andrew Forsyth and Pim Brouwers), and the National Institute on Alcohol Abuse and Alcoholism (Kendall Bryant). This research study was scientifically reviewed by the ATN’s Behavioral Leadership Groups. The authors acknowledge the ATN Coordinating Center at the University of Alabama at Birmingham, which is funded by grant U01 HD40533 (Craig Wilson and Cindy Partlow); the ATN Data and Operations Center at Westat, Inc. (Jim Korelitz and Barbara Driver) and Jacqueline Loeb, protocol specialist; the Community Advisory Board; and the subjects who participated in the study. The following ATN sites participated in this study: University of South Florida (Pat Emmanuel, Amayvis Rebolledo, and Tammy Myers), Children’s Hospital Los Angeles (Marvin Belzer, Diane Tucker, Nancy Flores, Julie McAvoy, and Michelle Bradford); Children’s National Medical Center (Larry D’Angelo and Connie Trexler), Children’s Hospital of Philadelphia (Steven Douglas, Mary Tanney, and Adrienne DiBenedetto), CORE Center/John H. Stroger Hospital (Jaime Martinez, Lisa Henry-Reid, Kelly Bojan, and Rachel Jackson), University of Puerto Rico (Irma Febo and Hazel Ayala), Montefiore Medical Center (Donna Futterman, Elizabeth Bruce, and Maria Campos), Mt. Sinai Medical Center (John Steever, Mary Geiger, and Jamie Kyei-Frimpong), University of California San Francisco (Barbara Moscicki and JB Molaghan), Tulane University (Sue Ellen Abdalian, Leslie Kozina, Alyne Baker, Brenda Andrews, and Trina Jeanjacques), University of Maryland Baltimore (Ligia Peralta, Reshma Gorle, and Leonel Flores), University of Miami (Larry Friedman, Donna Maturo, and Hanna Major-Wilson), Children’s Diagnostic and Treatment Center (Ana Puga, Esmine Downer, and Amy Inman), St. Jude Children’s Research Hospital (Pat Flynn, Mary Dillard, and Carla London), and Children’s Memorial Hospital (Rob Garofalo and Julia Brennan).
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