AIDS and Behavior

, Volume 16, Issue 8, pp 2267–2271 | Cite as

Bipolar Disorder is Associated with HIV Transmission Risk Behavior Among Patients in Treatment for HIV

  • Christina S. Meade
  • Lisa A. Bevilacqua
  • Mary D. Key
Brief Report


This study examined HIV transmission risk behavior among 63 patients with bipolar disorder (BD), major depressive disorder, and no mood disorder; half had substance use disorders (SUDs). Patients with BD were more likely than others to report unprotected intercourse with HIV-negative partners and <95 % adherence to antiretroviral medications. In multivariate models, BD and SUD were independent predictors of both risk behaviors. Participants with poorer medication adherence were more likely to have detectable HIV viral loads and unprotected intercourse with HIV-negative partners. Patients with BD deserve careful evaluation and HIV prevention services to reduce HIV transmission risk behaviors.


HIV/AIDS Bipolar disorder HIV transmission risk behavior Mood disorders Substance dependence 



This study was funded by grants K23-DA028660 and P30-AI064518 from the National Institutes of Health. Preliminary data from this study were presented at the 6th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention in Rome, Italy (July 17–20, 2011).

Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Christina S. Meade
    • 1
    • 2
  • Lisa A. Bevilacqua
    • 2
  • Mary D. Key
    • 2
  1. 1.Department of Psychiatry & Behavioral SciencesDuke University School of MedicineDurhamUSA
  2. 2.Duke Global Health InstituteDurhamUSA

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