AIDS and Behavior

, Volume 16, Issue 8, pp 2171–2180 | Cite as

OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

  • Nicole R. Nugent
  • Michelle A. Lally
  • Larry Brown
  • Valerie S. Knopik
  • John E. McGeary
Original Paper


Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.


HIV Binge drinking PTSD OPRM1 Gene 



This research was funded by a 2008 developmental grant from the Lifespan/Tufts/Brown Center for AIDS Research. The project described was supported by Grant Number P30AI042853 from the National Institute Of Allergy And Infectious Diseases. Content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Allergy And Infectious Diseases or the National Institute of Health. Dr. Nugent is supported by US-NIMH K01 MH087240. Work was supported by 1S10RR023457 and Shared equipment grants (ShEEP) from the Medical Research Service of the Department of Veteran Affairs, awarded to J. E. McGeary. This material is the result of work supported with resources and the use of facilities at the Providence VA Medical Center.


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Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  • Nicole R. Nugent
    • 1
    • 2
    • 3
  • Michelle A. Lally
    • 4
    • 5
  • Larry Brown
    • 2
    • 3
  • Valerie S. Knopik
    • 1
    • 2
    • 3
  • John E. McGeary
    • 1
    • 3
    • 6
  1. 1.Division of Behavioral Genetics, Department of PsychiatryRhode Island HospitalProvidenceUSA
  2. 2.Bradley/Hasbro Research CenterRhode Island HospitalProvidenceUSA
  3. 3.Department of Psychiatry and Human BehaviorAlpert Brown Medical SchoolProvidenceUSA
  4. 4.Miriam HospitalProvidenceUSA
  5. 5.Department of MedicineAlpert Brown Medical SchoolProvidenceUSA
  6. 6.Department of Veterans AffairsProvidence VA Medical Center, Research ServiceProvidenceUSA

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