AIDS and Behavior

, Volume 15, Issue 5, pp 919–929

A Preliminary Randomized Controlled Trial of a Nurse-Delivered Medication Adherence Intervention Among HIV-Positive Outpatients Initiating Antiretroviral Therapy in Beijing, China

  • Jane M. Simoni
  • Wei-Ti Chen
  • David Huh
  • Karen I. Fredriksen-Goldsen
  • Cynthia Pearson
  • Hongxin Zhao
  • Cheng-Shi Shiu
  • Xin Wang
  • Fujie Zhang
Original Paper

Abstract

We evaluated a nurse-delivered adherence intervention in a preliminary randomized controlled trial among 70 HIV-positive outpatients initiating antiretroviral therapy (ART) in Beijing, China. In both arms, participants received a 30-min educational session, a pillbox, and a referral to a peer support group. In the enhanced arm, participants could choose an electronic reminder device, three sessions of counseling either alone or with a treatment adherence partner, or both reminder and counseling. Survey assessments and blood draws occurred at baseline, post-intervention (13 weeks), and follow-up (25 weeks). Primary outcomes were 7-day and 30-day adherence assessed by self-report and electronic drug monitoring (EDM), and secondary outcomes were HIV-1 RNA viral load and CD4 count. The intervention was feasible and well received. It led to some improvement in self-reported and EDM-assessed adherence but not the biological outcomes. Providing counseling and facilitating the use of electronic reminders to patients initiating ART merits further investigation as a culturally viable means of promoting adherence in China.

Keywords

HIV/AIDS Adherence Counseling China Nursing 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jane M. Simoni
    • 1
  • Wei-Ti Chen
    • 2
  • David Huh
    • 1
  • Karen I. Fredriksen-Goldsen
    • 3
  • Cynthia Pearson
    • 3
  • Hongxin Zhao
    • 4
  • Cheng-Shi Shiu
    • 5
  • Xin Wang
    • 4
  • Fujie Zhang
    • 6
  1. 1.Department of PsychologyUniversity of WashingtonSeattleUSA
  2. 2.Department of Family and Child Nursing, School of NursingUniversity of WashingtonSeattleUSA
  3. 3.School of Social WorkUniversity of WashingtonSeattleUSA
  4. 4.Institute of Infectious DiseasesCapital Medical University, Ditan HospitalBeijingChina
  5. 5.School of Social Service AdministrationUniversity of ChicagoChicagoUSA
  6. 6.Division of Treatment and CareNational Center for AIDS/STD Control and PreventionBeijingChina

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